Janssens Katrien, ten Dijke Peter, Janssens Sophie, Van Hul Wim
Department of Medical Genetics, University of Antwerp, Campus Drie Eiken, 2610 Antwerp, Belgium.
Endocr Rev. 2005 Oct;26(6):743-74. doi: 10.1210/er.2004-0001. Epub 2005 May 18.
TGF-beta1 is a ubiquitous growth factor that is implicated in the control of proliferation, migration, differentiation, and survival of many different cell types. It influences such diverse processes as embryogenesis, angiogenesis, inflammation, and wound healing. In skeletal tissue, TGF-beta1 plays a major role in development and maintenance, affecting both cartilage and bone metabolism, the latter being the subject of this review. Because it affects both cells of the osteoblast and osteoclast lineage, TGF-beta1 is one of the most important factors in the bone environment, helping to retain the balance between the dynamic processes of bone resorption and bone formation. Many seemingly contradictory reports have been published on the exact functioning of TGF-beta1 in the bone milieu. This review provides an overall picture of the bone-specific actions of TGF-beta1 and reconciles experimental discrepancies that have been reported for this multifunctional cytokine.
转化生长因子β1（TGF-β1）是一种广泛存在的生长因子，参与调控多种不同细胞类型的增殖、迁移、分化和存活。它影响着诸如胚胎发育、血管生成、炎症和伤口愈合等多种不同的过程。在骨骼组织中，TGF-β1在发育和维持过程中发挥着重要作用，影响软骨和骨代谢，后者是本综述的主题。由于TGF-β1影响成骨细胞和破骨细胞谱系的细胞，它是骨环境中最重要的因子之一，有助于维持骨吸收和骨形成动态过程之间的平衡。关于TGF-β1在骨微环境中的确切功能，已经发表了许多看似相互矛盾的报道。本综述提供了TGF-β1在骨特异性作用的总体情况，并协调了针对这种多功能细胞因子所报道的实验差异。
