Dye B A, Schober S E, Dillon C F, Jones R L, Fryar C, McDowell M, Sinks T H
Centers for Disease Control and Prevention/National Center for Health Statistics, Hyattsville, MD 20782, USA.
Occup Environ Med. 2005 Jun;62(6):368-75. doi: 10.1136/oem.2004.016832.
Mercury amalgam dental restorations have been used by dentists since the mid 19th century and issues on safety continue to be periodically debated within the scientific and public health communities. Previous studies have reported a positive association between urine mercury levels and the number of dental amalgams, but this relation has never been described in a nationally representative sample in the United States.
Using household interview, dietary interview, dental examination, and laboratory data from the 1999-2000 National Health and Nutrition Examination Survey (NHANES), the association between mercury concentrations and dental restorations was examined in US women of reproductive age.
In women of childbearing age, approximately 13% of all posterior dental surfaces were restored with amalgams and the average urinary mercury level in women was low (1.34 microg/l). It is estimated that an increase of 1.8 microg/l in the log transformed values for mercury in urine would occur for each 10 dental surfaces restored with amalgam.
Although the findings do not address the important issues of adverse health effects at low thresholds of mercury exposure, they do provide important reference data that should contribute significantly to the ongoing scientific and public health policy debate on the use of dental amalgams in the USA.
自19世纪中叶以来,牙医们一直使用汞合金补牙材料,其安全性问题在科学界和公共卫生界仍不时引发争论。此前的研究报告称尿汞水平与补牙用汞合金数量之间存在正相关关系,但在美国具有全国代表性的样本中,这一关系从未得到描述。
利用1999 - 2000年国家健康与营养检查调查(NHANES)中的家庭访谈、饮食访谈、牙科检查及实验室数据,对美国育龄女性汞浓度与补牙材料之间的关联进行了研究。
在育龄女性中,所有后牙表面约13%用汞合金补牙,女性尿汞平均水平较低(1.34微克/升)。据估计,每多用汞合金补牙10个牙面,尿汞对数转换值会增加1.8微克/升。
尽管这些研究结果未涉及汞低剂量暴露对健康产生不良影响这一重要问题,但它们确实提供了重要的参考数据,应该会对美国正在进行的关于使用汞合金补牙的科学和公共卫生政策辩论有很大帮助。