Barkovich A J
Department of Radiology, University of California, San Francisco 94143-0625.
AJNR Am J Neuroradiol. 1992 May-Jun;13(3):959-72; discussion 973-5.
To determine the CT and MR characteristics of the brains of infants who have suffered profound asphyxia and correlate those characteristics with pathophysiologic processes.
MR and CT scans of 16 patients who suffered profound hypoxic-ischemic injury in the perinatal (12 patients) and postnatal (4 patients) periods were retrospectively reviewed in a search for characteristic imaging features.
Injury in the perinatal period: subacute MR showed short T1 and T2 in the ventral lateral thalami, posterolateral lentiform nuclei, posterior mesencephali, and hippocampi; MR 1 to 16 years after injury showed atrophy or T2 prolongation in the aforementioned regions, the lateral geniculate nuclei and perirolandic cerebral cortex. Asphyxia later in infancy: subacute MR showed T2 prolongation in the corpus striatum and most of the cerebral cortex (perirolandic sparing); MR weeks to months later showed atrophy of the aforementioned areas, the lateral geniculate nuclei and hippocampi. Acute CT in both groups showed basal ganglia hypodensity.
The injury patterns observed in neonates and infants with profound hypoxic-ischemic injury vary with the age of the patient at the time of the injury. The change in pattern of damage is suggested to be the result of structural and physiologic changes in the maturing brain. The patterns appear to be consistent and are well demonstrated by MR.
确定患有严重窒息的婴儿大脑的CT和MR特征，并将这些特征与病理生理过程相关联。
回顾性分析16例在围产期（12例）和出生后（4例）遭受严重缺氧缺血性损伤的患者的MR和CT扫描，以寻找特征性影像学表现。
围产期损伤：亚急性期MR显示腹外侧丘脑、后外侧豆状核、中脑后部和海马体T1和T2缩短；损伤后1至16年的MR显示上述区域、外侧膝状体和中央旁大脑皮质萎缩或T2延长。婴儿期后期窒息：亚急性期MR显示纹状体和大部分大脑皮质（中央旁区未受累）T2延长；数周至数月后的MR显示上述区域、外侧膝状体和海马体萎缩。两组的急性CT均显示基底节低密度。
患有严重缺氧缺血性损伤的新生儿和婴儿的损伤模式因损伤时患者的年龄而异。损伤模式的变化被认为是成熟大脑结构和生理变化的结果。这些模式似乎是一致的，并且MR能很好地显示。
