Barkovich A J, Westmark K, Partridge C, Sola A, Ferriero D M
Department of Radiology, University of California San Francisco 94143-0628, USA.
AJNR Am J Neuroradiol. 1995 Mar;16(3):427-38.
To determine whether one can detect hypoxic-ischemic brain injury by MR in the first 10 days of life and to identify patterns of injury in affected neonates.
Standard T1- and T2-weighted MR sequences that were performed in the first 10 days of life in 20 patients who suffered hypoxia/ischemia in the intrapartum or neonatal periods were reviewed retrospectively. Images were evaluated for patterns of signal changes.
Four patients had normal findings and were clinically healthy. The remaining 16 patients were divided into four groups based on pattern of injury: (a) primarily deep gray matter involvement; (b) primarily cortical involvement; (c) primarily periventricular white matter injury; and (d) mixed injury pattern. Two patients had appearances that suggested prepartum injury. T1 shortening was seen in injured tissue as early as 3 days after injury. T2 shortening did not appear until 6 or 7 days after injury.
MR can show brain damage in asphyxiated neonates during the first 10 days of life and shows early appearances of several patterns of brain injury.
确定在出生后的头10天内能否通过磁共振成像（MR）检测出缺氧缺血性脑损伤，并识别受影响新生儿的损伤模式。
回顾性分析20例在产时或新生儿期遭受缺氧/缺血的患者在出生后头10天内进行的标准T1加权和T2加权MR序列。对图像的信号变化模式进行评估。
4例患者检查结果正常且临床健康。其余16例患者根据损伤模式分为四组：（a）主要累及深部灰质；（b）主要累及皮质；（c）主要为脑室周围白质损伤；（d）混合损伤模式。2例患者的表现提示产前损伤。损伤后最早3天在受损组织中可见T1缩短。T2缩短直到损伤后6或7天才出现。
MR能够在窒息新生儿出生后的头10天内显示脑损伤，并显示出几种脑损伤模式的早期表现。
