Gorini G, De Gregorio G, Silvestri S, Chellini E, Cupelli V, Seniori Costantini A
Unit of Occupational and Environmental Epidemiology, Centre for Study and Prevention of Cancer (CSPO), via di S. Salvi, 12, 50135 Florence, Italy.
Eur J Cancer Prev. 2005 Jun;14(3):195-9. doi: 10.1097/00008469-200506000-00001.
This study analyses survival of Tuscan residents (Italy, 3.5 million population) diagnosed by histological examination with malignant pleural mesothelioma (MPM) during the period 1988-2000, and recorded in the Tuscan Malignant Mesothelioma Register. The aim was to establish the prognostic role of demographic, diagnostic and asbestos exposure variables. During 1988-2000, 381 MPM cases were recorded (318 men; 63 women). Vital status was ascertained up to 31 December 2002. No cases were lost to follow-up. Median survival of certain MPM was 324 days (11 months; 95% CI 297-366); 45.7% (95% CI 40.6-50.6%) survived more than 1 year; 24.2% (95% CI 20.0-28.5%) more than 2 years. In univariate and multivariate analyses survival was associated with histological subtype (epithelioid subtype had the longest survival). Gender, age, period of diagnosis, hospital of diagnosis and asbestos exposure did not show significant effects. Therapeutic information was available for patients of the period 1997-2000. There was no significant difference in survival between treated versus untreated patients. In conclusion, no advance in prognosis at the population level in the most recent period can be suggested on the basis of the data available to the Tuscan Malignant Mesothelioma Register.
本研究分析了1988年至2000年期间在托斯卡纳恶性间皮瘤登记处记录的、经组织学检查确诊为恶性胸膜间皮瘤（MPM）的托斯卡纳居民（意大利，350万人口）的生存情况。目的是确定人口统计学、诊断和石棉暴露变量的预后作用。1988年至2000年期间，记录了381例MPM病例（318例男性；63例女性）。截至2002年12月31日确定了生命状态。无病例失访。特定MPM的中位生存期为324天（11个月；95%CI 297 - 366）；45.7%（95%CI 40.6 - 50.6%）存活超过1年；24.2%（95%CI 20.0 - 28.5%）存活超过2年。在单变量和多变量分析中，生存与组织学亚型相关（上皮样亚型生存期最长）。性别、年龄、诊断时期、诊断医院和石棉暴露未显示出显著影响。可获得1997年至2000年期间患者的治疗信息。治疗组与未治疗组患者的生存无显著差异。总之，根据托斯卡纳恶性间皮瘤登记处现有的数据，无法表明近期在人群水平上预后有改善。
