Melnikova Natalia, Wu Jennifer, Kaye Wendy, Orr Maureen
Agency for Toxic Substances and Disease Registry, Division of Toxicology and Health Sciences, Buford Highway, Atlanta, GA 30341, USA.
ISRN Oncol. 2013 Mar 28;2013:325409. doi: 10.1155/2013/325409. Print 2013.
Objective. To evaluate the validity of proxy interviews in obtaining information on persons with rapidly fatal diseases such as malignant mesothelioma (MM). Methods. Persons with MM diagnosed in 2002 through 2005 in New York and New Jersey and 1997-2004 in Wisconsin were eligible for inclusion in the project. Persons with MM and their family member proxy were interviewed using the same questionnaire designed by ATSDR to collect information on potential direct or indirect occupational and environmental exposure to asbestos, genetic, and health related malignancy predisposition, and exposure to tobacco products. Descriptive statistics and the McNemar/Durkalski test were used to analyze 33 matched pairs. Results. The overall study confirmed a generally high ability of proxies to give interviews of comparable quality and completeness when asked dichotomous questions. The reliability of information collected from proxies varied by topic and family relationship. Conclusions. Family proxy interviews, using dichotomous responses, can serve as an acceptable source of information about health and exposure-related risk factors for MM.
目的。评估代理访谈在获取有关恶性间皮瘤（MM）等快速致死性疾病患者信息方面的有效性。方法。2002年至2005年在纽约和新泽西州以及1997年至2004年在威斯康星州被诊断为MM的患者有资格纳入该项目。使用美国毒物与疾病登记署（ATSDR）设计的相同问卷对MM患者及其家庭成员代理进行访谈，以收集有关潜在的直接或间接职业和环境石棉暴露、遗传以及与健康相关的恶性肿瘤易感性和烟草制品暴露的信息。使用描述性统计和麦克尼马尔/杜尔卡尔斯基检验分析33对匹配数据。结果。总体研究证实，当被问及二分问题时，代理通常具有提供质量和完整性相当的访谈的较高能力。从代理收集的信息的可靠性因主题和家庭关系而异。结论。使用二分回答的家庭代理访谈可作为MM健康和暴露相关风险因素信息的可接受来源。
