Fesenmeier Michael F, Coppage Kristin H, Lambers Donna S, Barton John R, Sibai Baha M
Department of Obstetrics and Gynecology, University of Cincinnati, Ohio 45267-0526, USA.
Am J Obstet Gynecol. 2005 May;192(5):1416-9. doi: 10.1016/j.ajog.2004.12.035.
The purpose of this study was to determine the demographics, clinical presentation, and maternal and neonatal outcomes in patients who were diagnosed with acute fatty liver of pregnancy over a 10-year period.
This was a multicenter retrospective study of women with the diagnosis of acute fatty liver of pregnancy. Records were reviewed for symptoms, laboratory findings, clinical course, and maternal and perinatal outcomes.
Sixteen cases of acute fatty liver of pregnancy were identified. Three of the 16 cases had multiple gestations (18%). Eleven of the 16 cases were diagnosed in the antepartum period, and 5 cases were diagnosed within 4 days after delivery. Nausea and vomiting were the most common symptoms (75%). There were 2 maternal deaths (12.5%) and 3 fetal deaths (15%).
We recommend that patients with persistent nausea, vomiting, or epigastric pain in the third trimester receive evaluation of liver enzymes, renal function, and a complete blood count to rule out the diagnosis of acute fatty liver of pregnancy.
本研究旨在确定在10年期间被诊断为妊娠急性脂肪肝的患者的人口统计学特征、临床表现以及母婴结局。
这是一项对诊断为妊娠急性脂肪肝的女性进行的多中心回顾性研究。对症状、实验室检查结果、临床病程以及母婴围产期结局的记录进行了回顾。
共确定16例妊娠急性脂肪肝病例。16例中有3例为多胎妊娠（18%）。16例中有11例在产前被诊断，5例在产后4天内被诊断。恶心和呕吐是最常见的症状（75%）。有2例孕产妇死亡（12.5%）和3例胎儿死亡（15%）。
我们建议，妊娠晚期持续出现恶心、呕吐或上腹部疼痛的患者应接受肝酶、肾功能及全血细胞计数检查，以排除妊娠急性脂肪肝的诊断。
