Wang Wenjung, Datta Hia, Sussman Elyse
Department of Speech and Hearing Sciences, The Graduate Center of the City University of New York, 365 5th Avenue, New York, NY 10016, USA.
Clin Neurophysiol. 2005 Jul;116(7):1695-706. doi: 10.1016/j.clinph.2005.03.008.
The length of the temporal window integrating successive auditory stimuli into unitary percepts has been estimated to be less than 200 ms in adults. The aim of the study was to investigate the development of the integrating window in children to determine whether it is similar to young adults.
A modified auditory oddball paradigm was presented at a rapid (150-400 ms) onset-to-onset pace during recording of electroencephalogram in two groups of children (aged 5-8 and 9-11 years) and one group of adults. Latencies and amplitudes of the P1, N1, and the mismatch negativity (MMN) components of event-related brain potentials (ERPs) were measured.
The length of the temporal window of integration (TWI) was shorter in adults (<200 ms) than older children (<300 ms in 9-11-year-olds) and younger children (<350 ms in the 5-8-year-olds). In addition, age-related changes were found in the latency and amplitude of the ERP components.
The results demonstrate a general maturational development of the auditory evoked potentials and also a specific maturational process for temporal encoding of information in auditory cortex.
Rapid stimulus presentation rates can be successfully used in school-aged children to study neural mechanisms of auditory processes.
据估计，成年人将连续听觉刺激整合为单一感知的时间窗口长度小于200毫秒。本研究的目的是调查儿童中整合窗口的发育情况，以确定其是否与年轻成年人相似。
在两组儿童（5至8岁和9至11岁）和一组成年人进行脑电图记录期间，以快速（150至400毫秒）的刺激起始间隔呈现改良的听觉Oddball范式。测量事件相关脑电位（ERP）的P1、N1和失配负波（MMN）成分的潜伏期和振幅。
成年人的整合时间窗口（TWI）长度（<200毫秒）比大龄儿童（9至11岁儿童<300毫秒）和小龄儿童（5至8岁儿童<350毫秒）短。此外，还发现ERP成分的潜伏期和振幅存在与年龄相关的变化。
结果表明听觉诱发电位存在一般的成熟发育，以及听觉皮层中信息时间编码的特定成熟过程。
快速刺激呈现率可成功用于学龄儿童，以研究听觉过程的神经机制。
