Jossinet Fabrice, Westhof Eric
Institut de Biologie Moléculaire et Cellulaire du CNRS, UPR9002, Université Louis Pasteur, F-67084 Strasbourg, France.
Bioinformatics. 2005 Aug 1;21(15):3320-1. doi: 10.1093/bioinformatics/bti504. Epub 2005 May 19.
Efficient RNA sequence manipulations (such as multiple alignments) need to be constrained by rules of RNA structure folding. The structural knowledge has increased dramatically in the last years with the accumulation of several large RNA structures similar to those of the bacterial ribosome subunits. However, no tool in the RNA community provides an easy way to link and integrate progress made at the sequence level using the available three-dimensional information. Sequence to Structure (S2S) proposes a framework in which an user can easily display, manipulate and interconnect heterogeneous RNA data, such as multiple sequence alignments, secondary and tertiary structures. S2S has been implemented using the Java language and has been developed and tested under UNIX systems, such as Linux and MacOSX.
S2S is available at http://bioinformatics.org/S2S/.
高效的RNA序列操作（如多重比对）需要受到RNA结构折叠规则的限制。随着与细菌核糖体亚基类似的多个大型RNA结构的积累，近年来结构知识有了显著增加。然而，RNA领域中没有工具能提供一种简单的方法，利用现有的三维信息来连接和整合在序列层面取得的进展。序列到结构（S2S）提出了一个框架，用户可以在其中轻松显示、操作和互连异构RNA数据，如多重序列比对、二级和三级结构。S2S已使用Java语言实现，并在UNIX系统（如Linux和MacOSX）下开发和测试。
