Creuzet Sophie, Vincent Christine, Couly Gérard
Institut d'Embryologie Cellulaire et Molèculaire du CNRS et du Collge de France, UMR 7128, Nogent-sur-Marne cedex, France.
Int J Dev Biol. 2005;49(2-3):161-71. doi: 10.1387/ijdb.041937sc.
In vertebrates, the eye is an ectodermal compound structure associating neurectodermal and placodal anlagen. In addition, it benefits early on from a mesenchymal ectoderm-derived component, the neural crest. In this respect, the construction of chimeras between quail and chick has been a turning point, instrumental in appraising the contribution of the cephalic neural crest to the development of ocular and periocular structures. Given the variety of crest derivatives underscored in the developing eye, this study illustrates the fascinating ability of this unique structure to finely adapt its differentiation to microenvironmental cues. This analysis of neural crest cell contribution to ocular development emphasizes their paramount role to design the anterior segment of the eye, supply refracting media and contribute to the homeostasy of the anterior optic chamber.
在脊椎动物中，眼睛是一种外胚层复合结构，由神经外胚层和基板原基组成。此外，它早期受益于间充质外胚层衍生成分，即神经嵴。在这方面，鹌鹑和鸡之间嵌合体的构建是一个转折点，有助于评估头部神经嵴对眼和眼周结构发育的贡献。鉴于发育中的眼睛中神经嵴衍生物的多样性，本研究说明了这种独特结构根据微环境线索精细调整其分化的迷人能力。对神经嵴细胞在眼部发育中贡献的分析强调了它们在设计眼前节、提供屈光介质以及维持眼前房内环境稳定方面的首要作用。
