Spector Z Z, Emami K, Fischer M C, Zhu J, Ishii M, Vahdat V, Yu J, Kadlecek S, Driehuys B, Lipson D A, Gefter W, Shrager J, Rizi R R
Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6100, USA.
Magn Reson Med. 2005 Jun;53(6):1341-6. doi: 10.1002/mrm.20514.
In this experiment, Sprague-Dawley rats with elastase-induced emphysema were imaged using hyperpolarized (3)He MRI. Regional fractional ventilation r, the fraction of gas replaced with a single tidal breath, was calculated from a series of images in a wash-in study of hyperpolarized gas. We compared the regional fractional ventilation in these emphysematous rats to the regional fractional ventilations we calculated from a previous baseline study in healthy Sprague-Dawley rats. We found that there were differences in the maps of fractional ventilation and its associated frequency distribution between the healthy and emphysematous rat lungs. Fractional ventilation tended to be much lower in emphysematous rats than in normal rats. With this information, we can use data on fractional ventilation to regionally distinguish between healthy and emphysematous portions of the lung. The successful implementation of such a technique on a rat model could lead to work toward the future implementation of this technique in human patients.
在本实验中，使用超极化（3）He磁共振成像对患有弹性蛋白酶诱导性肺气肿的斯普拉格-道利大鼠进行成像。区域分数通气率r，即单次潮气量所替代的气体分数，是通过超极化气体的洗入研究中的一系列图像计算得出的。我们将这些肺气肿大鼠的区域分数通气与我们之前在健康斯普拉格-道利大鼠的基线研究中计算出的区域分数通气进行了比较。我们发现，健康大鼠和肺气肿大鼠的肺脏在分数通气图及其相关频率分布方面存在差异。肺气肿大鼠的分数通气往往比正常大鼠低得多。有了这些信息，我们可以利用分数通气数据在区域上区分肺的健康部分和肺气肿部分。在大鼠模型上成功实施这种技术可能会推动未来在人类患者中应用该技术的研究工作。
