Dupuich David, Berthezène Yves, Clouet Pierre-Louis, Stupar Vasile, Canet Emmanuelle, Crémillieux Yannick
Laboratoire de RMN, CNRS 5012, Université Lyon-1, Villeurbanne, France.
Magn Reson Med. 2003 Oct;50(4):777-83. doi: 10.1002/mrm.10590.
Dynamic ventilation imaging using laser-polarized (3)He has a promising potential for elucidating the physiology and physiopathology of the lungs. In this study, a methodological approach is proposed for the assessment and quantification of local ventilation parameters. High-temporal-resolution coronal ventilation image series were obtained with a projection-reconstruction (PR) sequence combined with the sliding-window technique. After image series were processed, parametric pixel-by-pixel maps of the gas arrival time, filling time constant, inflation rate, and gas volume were generated. The acquisition technique and the signal processing procedure, which are referred to collectively as sliding pulmonary imaging for respiratory overview (SPIRO), were tested in vivo in healthy rat lungs using a contrast media injector for controlled (3)He flow and volume injection in the animal lungs. The same protocol was applied to broncho-constriction animal models using intravenous injection of methacholine solution. Inflation rate values measured in the lungs were found to decrease with increasing doses of injected methacholine solution. This study demonstrates that it is possible to obtain quantitative regional gas dynamic information using the SPIRO technique in a single polarized gas inspiration.
使用激光极化（3）He进行动态通气成像在阐明肺部生理和病理生理学方面具有广阔的潜力。在本研究中，提出了一种用于评估和量化局部通气参数的方法。通过结合滑动窗口技术的投影重建（PR）序列获得了高时间分辨率的冠状通气图像序列。在对图像序列进行处理后，生成了气体到达时间、充盈时间常数、充气率和气体体积的逐像素参数图。在健康大鼠肺部进行了体内测试，使用造影剂注射器在动物肺部进行受控的（3）He流量和体积注射，将采集技术和信号处理程序统称为用于呼吸概述的滑动肺部成像（SPIRO）。使用静脉注射乙酰甲胆碱溶液的相同方案应用于支气管收缩动物模型。发现随着注入的乙酰甲胆碱溶液剂量增加，肺部测量的充气率值降低。本研究表明，在单次极化气体吸入中使用SPIRO技术可以获得定量的区域气体动力学信息。
