van Asten Alphons J A M, van Dijk Jaap E
Department of Pathobiology, Division Pathology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, P.O. Box 80.158, 3508TD, Utrecht, The Netherlands.
FEMS Immunol Med Microbiol. 2005 Jun 1;44(3):251-9. doi: 10.1016/j.femsim.2005.02.002.
Whether an infection with Salmonella spp. leads to a disease largely depends on the virulence of the strain and the constitution of the host. The virulence of the strain is determined by so-called virulence factors. Whereas a number of virulence factors of Salmonella have been identified only recently, others have been studied for decades. These latter virulence factors i.e., virulence-plasmids, toxins, fimbriae and flagella are therefore referred to as "classic" virulence factors. Here we present an overview on the distribution of (genes coding for) these virulence factors among Salmonella spp. The pathogenicity islands of Salmonella are also reviewed, all be it briefly, since they contain a major part of the virulence genes.
感染沙门氏菌属是否会引发疾病很大程度上取决于菌株的毒力和宿主的体质。菌株的毒力由所谓的毒力因子决定。虽然沙门氏菌的一些毒力因子直到最近才被确定，但其他一些毒力因子已经研究了几十年。因此，这些后一种毒力因子，即毒力质粒、毒素、菌毛和鞭毛，被称为“经典”毒力因子。在此，我们概述了这些毒力因子（编码基因）在沙门氏菌属中的分布情况。沙门氏菌的致病岛也会被简要回顾，因为它们包含了大部分毒力基因。
