沙门氏菌是如何成为一种病原体的。
How Salmonella became a pathogen.
作者信息
Groisman E A, Ochman H
机构信息
Dept of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110-1093, USA.
出版信息
Trends Microbiol. 1997 Sep;5(9):343-9. doi: 10.1016/S0966-842X(97)01099-8.
PMID:9294889
Abstract
In many pathogens, virulence can be conferred by a single region of the genome. In contrast, the facultative intracellular lifestyle of Salmonella demands a large number of genes distributed around the chromosome. The evolution of Salmonella has been marked by the acquisition of several 'pathogenicity islands', each contributing to the unique virulence properties of this microorganism.
摘要
在许多病原体中，毒力可由基因组的单个区域赋予。相比之下，沙门氏菌的兼性细胞内生活方式需要大量分布在染色体周围的基因。沙门氏菌的进化以获得几个“致病岛”为特征，每个致病岛都对这种微生物独特的毒力特性有所贡献。
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