对一个旧孔隙的新看法。

A new view of an old pore.

作者信息

Bajjalieh Sandra

机构信息

Department of Pharmacology, University of Washington, D429 HSB, Box 357280, Seattle, Washington 98195.

出版信息

Cell. 2005 May 20;121(4):496-497. doi: 10.1016/j.cell.2005.05.002.

DOI:10.1016/j.cell.2005.05.002

PMID:15907459

Abstract

Despite reports suggesting a potential role in membrane fusion, the V(0) subunit of the (+)H/ATPase has remained an unlikely candidate for the fusion pore. In this issue of Cell, Hiesinger and coworkers (Hiesinger et al., 2005) present a forward genetic screen that reveals it to be necessary for synaptic vesicle fusion, independent of its role in vesicle acidification.

摘要

尽管有报道表明（+）H/ATP酶的V（0）亚基在膜融合中可能发挥作用，但它一直不太可能是融合孔的候选者。在本期《细胞》杂志中，希辛格及其同事（希辛格等人，2005年）进行了一项正向遗传学筛选，结果表明它对于突触小泡融合是必需的，且与其在小泡酸化中的作用无关。