泛醌对3-羟基-3-甲基戊二酰辅酶A还原酶活性的反馈型抑制作用
Feedback-type inhibition of activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase by ubiquinone.
作者信息
Omkumar R V, Gaikwad A S, Ramasarma T
机构信息
Department of Biochemistry, Indian Institute of Science, Bangalore.
出版信息
Biochem Biophys Res Commun. 1992 May 15;184(3):1280-7. doi: 10.1016/s0006-291x(05)80021-x.
PMID:1590790
Abstract
Accompanying the decrease in serum cholesterol and increase in concentration of ubiquinone in liver and its microsomes, the activity, but not the protein, of HMG-CoA reductase decreased in ubiquinone-supplemented rats. A soluble 58-kDa preparation of HMG-CoA reductase was partially inhibited on addition of ubiquinone indicating a possible feedback type of action.
摘要
伴随着血清胆固醇的降低以及肝脏及其微粒体中泛醌浓度的增加，在补充泛醌的大鼠中，HMG-CoA还原酶的活性降低，但蛋白质含量未变。添加泛醌后，一种58 kDa的可溶性HMG-CoA还原酶制剂受到部分抑制，这表明可能存在反馈作用类型。
Zotero 插件