Prikryl Radovan, Ceskova Eva, Kasparek Tomas, Kucerova Hana
Department of Psychiatry, Masaryk University, Faculty of Medicine and Faculty Hospital, Brno, Jihlavska 20, 625 00 Brno, Czech Republic.
J Psychiatr Res. 2006 Mar;40(2):141-6. doi: 10.1016/j.jpsychires.2005.03.008.
(a) To investigate the correlation between clinical symptoms and neurological soft signs in patients suffering from their first episode of schizophrenia and (b) to examine the relationship between soft signs and the reactivity of first episode treatment.
The trial included 92 male patients undergoing a first episode of schizophrenia. The clinical symptoms of the patients were rated on the positive and negative syndrome scale (PANSS). The PANSS scale was used to provide a measure for three syndromes: psychomotor poverty, disorganisation, and reality distortion. Neurological soft signs were assessed with the help of the neurological evaluation scale.
The findings corroborated significant positive correlations between soft neurological signs on the one hand and negative symptoms and reduced treatment response on the other.
Our study of the population of patients with first episode schizophrenia has corroborated the findings of those trials that found a correlation between neurological soft signs and the negative symptomatic dimension of schizophrenia. Another finding of the trial is that neurological soft signs were associated with poorer response to treatment of the first episode of schizophrenia.
（a）调查首次发作精神分裂症患者的临床症状与神经软体征之间的相关性；（b）研究软体征与首次发作治疗反应性之间的关系。
该试验纳入了92名首次发作精神分裂症的男性患者。采用阳性与阴性症状量表（PANSS）对患者的临床症状进行评分。PANSS量表用于衡量三种综合征：精神运动迟缓、紊乱和现实扭曲。借助神经评估量表评估神经软体征。
研究结果证实，一方面神经软体征与阴性症状之间存在显著正相关，另一方面与治疗反应降低也存在显著正相关。
我们对首次发作精神分裂症患者群体的研究证实了那些发现神经软体征与精神分裂症阴性症状维度之间存在相关性的试验结果。该试验的另一个发现是，神经软体征与首次发作精神分裂症治疗反应较差有关。
