Varambally S, Venkatasubramanian G, Thirthalli J, Janakiramaiah N, Gangadhar B N
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.
Acta Psychiatr Scand. 2006 Nov;114(5):352-6. doi: 10.1111/j.1600-0447.2006.00837.x.
Cerebellar neurological abnormalities in schizophrenia have been associated with severe negative symptoms, cognitive deficits, and smaller cerebellar volume. This study assessed the comparative discriminant validity between Cerebellar Soft Signs (CSS) vs. other neurological soft signs (ONSS) [in discriminating between schizophrenia patients and healthy controls] as well as the relationship between the soft signs and psychopathology.
Antipsychotic-naïve schizophrenia patients (n = 32) and healthy subjects (n = 32) were examined using International Co-Operative Ataxia Rating Scale and Neurological Evaluation Scale.
Mean CSS scores, ONSS total score, and Sensory Integration Signs sub-score were significantly higher in patients. Discriminant analysis revealed two CSS sub-scores (but none of the ONSS scores) to be significant (P < 0.0001) accounting for 78% of classification. CSS total score, Posture sub-score, and Oculomotor sub-score had significant positive correlation with negative syndrome score.
Findings support intrinsic cerebellar dysfunction in schizophrenia. The observations are discussed in relationship with cognitive dysmetria.
精神分裂症中的小脑神经功能异常与严重的阴性症状、认知缺陷以及较小的小脑体积有关。本研究评估了小脑软体征（CSS）与其他神经软体征（ONSS）在区分精神分裂症患者和健康对照方面的比较判别效度，以及软体征与精神病理学之间的关系。
使用国际合作共济失调评定量表和神经学评估量表对未服用抗精神病药物的精神分裂症患者（n = 32）和健康受试者（n = 32）进行检查。
患者的CSS平均得分、ONSS总分和感觉统合体征子得分显著更高。判别分析显示两个CSS子得分（但没有一个ONSS得分）具有显著性（P < 0.0001），占分类的78%。CSS总分、姿势子得分和动眼神经子得分与阴性综合征得分呈显著正相关。
研究结果支持精神分裂症存在内在小脑功能障碍。结合认知性辨距不良对这些观察结果进行了讨论。
