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本文引用的文献

1
The pH 6 antigen is an antiphagocytic factor produced by Yersinia pestis independent of Yersinia outer proteins and capsule antigen.pH6抗原是一种由鼠疫耶尔森菌产生的抗吞噬因子，与耶尔森菌外膜蛋白和荚膜抗原无关。
Infect Immun. 2004 Dec;72(12):7212-9. doi: 10.1128/IAI.72.12.7212-7219.2004.
2
Complete genome sequence of Yersinia pestis strain 91001, an isolate avirulent to humans.对人类无毒力的鼠疫耶尔森氏菌菌株91001的全基因组序列
DNA Res. 2004 Jun 30;11(3):179-97. doi: 10.1093/dnares/11.3.179.
3
Insights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis.通过与假结核耶尔森菌进行全基因组比较深入了解鼠疫耶尔森菌的进化。
Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13826-31. doi: 10.1073/pnas.0404012101. Epub 2004 Sep 9.
4
Genetics of metabolic variations between Yersinia pestis biovars and the proposal of a new biovar, microtus.鼠疫耶尔森氏菌生物变种间代谢差异的遗传学及新生物变种——田鼠变种的提议
J Bacteriol. 2004 Aug;186(15):5147-52. doi: 10.1128/JB.186.15.5147-5152.2004.
5
Identification of signature genes for rapid and specific characterization of Yersinia pestis.用于快速和特异性鉴定鼠疫耶尔森菌的特征性基因
Microbiol Immunol. 2004;48(4):263-9. doi: 10.1111/j.1348-0421.2004.tb03522.x.
6
Antigenicity analysis of different regions of the severe acute respiratory syndrome coronavirus nucleocapsid protein.严重急性呼吸综合征冠状病毒核衣壳蛋白不同区域的抗原性分析
Clin Chem. 2004 Jun;50(6):988-95. doi: 10.1373/clinchem.2004.031096. Epub 2004 Mar 30.
7
The yersiniae--a model genus to study the rapid evolution of bacterial pathogens.耶尔森氏菌属——研究细菌病原体快速进化的一个典型菌属。
Nat Rev Microbiol. 2003 Oct;1(1):55-64. doi: 10.1038/nrmicro730.
8
Analyzing antibody specificity with whole proteome microarrays.使用全蛋白质组微阵列分析抗体特异性。
Nat Biotechnol. 2003 Dec;21(12):1509-12. doi: 10.1038/nbt910. Epub 2003 Nov 9.
9
Immunological characterisation of sub-units of the Yersinia type III secretion apparatus.耶尔森氏菌III型分泌装置亚基的免疫学特性分析
Adv Exp Med Biol. 2003;529:415-7. doi: 10.1007/0-306-48416-1_82.
10
pH6 antigen of Yersinia pestis interacts with plasma lipoproteins and cell membranes.鼠疫耶尔森菌的pH6抗原与血浆脂蛋白和细胞膜相互作用。
J Lipid Res. 2003 Feb;44(2):320-30. doi: 10.1194/jlr.M200182-JLR200. Epub 2002 Nov 16.

用于分析针对鼠疫耶尔森氏菌活疫苗抗体反应的蛋白质微阵列。

Protein microarray for profiling antibody responses to Yersinia pestis live vaccine.

作者信息

Li Bei, Jiang Lingxiao, Song Qifeng, Yang Junxin, Chen Zeliang, Guo Zhaobiao, Zhou Dongsheng, Du Zongmin, Song Yajun, Wang Jin, Wang Hongxia, Yu Shouyi, Wang Jian, Yang Ruifu

机构信息

Laboratory of Analytical Microbiology, National Center for Biomedical Analysis, Army Center for Microbial Detection and Research, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.

出版信息

Infect Immun. 2005 Jun;73(6):3734-9. doi: 10.1128/IAI.73.6.3734-3739.2005.

DOI:10.1128/IAI.73.6.3734-3739.2005
PMID:15908403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1111848/
Abstract

A protein microarray representing 149 Yersinia pestis proteins was developed to profile antibody responses in EV76-immunized rabbits. Antibodies to 50 proteins were detected. There are 11 proteins besides F1 and V antigens to which the predominant antibody response occurred, and these proteins show promise for further evaluation as candidates for subunit vaccines and/or diagnostic antigens.

摘要

构建了一个包含149种鼠疫耶尔森菌蛋白的蛋白质微阵列，以分析经EV76免疫的兔体内的抗体反应。检测到针对50种蛋白的抗体。除F1和V抗原外，有11种蛋白引发了主要的抗体反应，这些蛋白有望作为亚单位疫苗和/或诊断抗原的候选物作进一步评估。