用于分析针对鼠疫耶尔森氏菌活疫苗抗体反应的蛋白质微阵列。
Protein microarray for profiling antibody responses to Yersinia pestis live vaccine.
作者信息
Li Bei, Jiang Lingxiao, Song Qifeng, Yang Junxin, Chen Zeliang, Guo Zhaobiao, Zhou Dongsheng, Du Zongmin, Song Yajun, Wang Jin, Wang Hongxia, Yu Shouyi, Wang Jian, Yang Ruifu
机构信息
Laboratory of Analytical Microbiology, National Center for Biomedical Analysis, Army Center for Microbial Detection and Research, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
出版信息
Infect Immun. 2005 Jun;73(6):3734-9. doi: 10.1128/IAI.73.6.3734-3739.2005.
Abstract
A protein microarray representing 149 Yersinia pestis proteins was developed to profile antibody responses in EV76-immunized rabbits. Antibodies to 50 proteins were detected. There are 11 proteins besides F1 and V antigens to which the predominant antibody response occurred, and these proteins show promise for further evaluation as candidates for subunit vaccines and/or diagnostic antigens.
摘要
构建了一个包含149种鼠疫耶尔森菌蛋白的蛋白质微阵列，以分析经EV76免疫的兔体内的抗体反应。检测到针对50种蛋白的抗体。除F1和V抗原外，有11种蛋白引发了主要的抗体反应，这些蛋白有望作为亚单位疫苗和/或诊断抗原的候选物作进一步评估。
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