结核分枝杆菌对在小鼠肺部生长的反应。
responses of mycobacterium tuberculosis to growth in the mouse lung.
作者信息
Dubnau Eugenie, Chan John, Mohan V P, Smith Issar
机构信息
The Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA.
出版信息
Infect Immun. 2005 Jun;73(6):3754-7. doi: 10.1128/IAI.73.6.3754-3757.2005.
Abstract
Using a promoter trap, we have identified 56 Mycobacterium tuberculosis genes preferentially expressed in the mouse lung. Quantitative real-time PCR showed that RNA levels of several genes were higher from bacteria growing in mouse lungs than from broth cultures. These results support the current hypothesis that Mycobacterium tuberculosis utilizes fatty acids as a carbon source in the mouse lung.
摘要
利用启动子捕获技术，我们鉴定出了56个在小鼠肺中优先表达的结核分枝杆菌基因。定量实时PCR显示，与肉汤培养物相比，小鼠肺中生长的细菌中几个基因的RNA水平更高。这些结果支持了目前的假说，即结核分枝杆菌在小鼠肺中利用脂肪酸作为碳源。
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