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本文引用的文献

1
Differential expression of iron-, carbon-, and oxygen-responsive mycobacterial genes in the lungs of chronically infected mice and tuberculosis patients.铁、碳和氧反应性分枝杆菌基因在慢性感染小鼠和肺结核患者肺部的差异表达。
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14321-6. doi: 10.1073/pnas.2436197100. Epub 2003 Nov 17.
2
Biochemical differentiation of Mycobacterium tuberculosis grown in vivo and in vitro.体内和体外培养的结核分枝杆菌的生化分化
J Bacteriol. 1956 Aug;72(2):132-41. doi: 10.1128/jb.72.2.132-141.1956.
3
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment.结核分枝杆菌在巨噬细胞内的转录适应性：对吞噬体环境的见解
J Exp Med. 2003 Sep 1;198(5):693-704. doi: 10.1084/jem.20030846.
4
Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence.小鼠肺部Th1介导的免疫反应表达会诱导出结核分枝杆菌非复制性持续状态所特有的转录模式。
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):241-6. doi: 10.1073/pnas.0136863100. Epub 2002 Dec 27.
5
ideR, An essential gene in mycobacterium tuberculosis: role of IdeR in iron-dependent gene expression, iron metabolism, and oxidative stress response.ideR，结核分枝杆菌中的一个必需基因：ideR在铁依赖性基因表达、铁代谢及氧化应激反应中的作用
Infect Immun. 2002 Jul;70(7):3371-81. doi: 10.1128/IAI.70.7.3371-3381.2002.
6
Mycobacterium tuberculosis genes induced during infection of human macrophages.结核分枝杆菌在人类巨噬细胞感染过程中诱导表达的基因。
Infect Immun. 2002 Jun;70(6):2787-95. doi: 10.1128/IAI.70.6.2787-2795.2002.
7
Mycobacterium tuberculosis WhiB3 interacts with RpoV to affect host survival but is dispensable for in vivo growth.结核分枝杆菌WhiB3与RpoV相互作用以影响宿主存活，但对体内生长并非必需。
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3147-52. doi: 10.1073/pnas.052705399.
8
The Mycobacterium tuberculosis IdeR is a dual functional regulator that controls transcription of genes involved in iron acquisition, iron storage and survival in macrophages.结核分枝杆菌IdeR是一种双功能调节因子，可控制参与铁摄取、铁储存及在巨噬细胞中存活的基因的转录。
Mol Microbiol. 2001 Nov;42(3):851-65. doi: 10.1046/j.1365-2958.2001.02684.x.
9
Identification and mutagenesis by allelic exchange of choE, encoding a cholesterol oxidase from the intracellular pathogen Rhodococcus equi.通过等位基因交换对编码来自细胞内病原体马红球菌的胆固醇氧化酶的choE进行鉴定和诱变。
J Bacteriol. 2001 Aug;183(16):4796-805. doi: 10.1128/JB.183.16.4796-4805.2001.
10
Protection of mice with a tuberculosis subunit vaccine based on a fusion protein of antigen 85b and esat-6.基于抗原85b与早期分泌性抗原靶6融合蛋白的结核亚单位疫苗对小鼠的保护作用
Infect Immun. 2001 May;69(5):2773-8. doi: 10.1128/IAI.69.5.2773-2778.2001.

结核分枝杆菌对在小鼠肺部生长的反应。

responses of mycobacterium tuberculosis to growth in the mouse lung.

作者信息

Dubnau Eugenie, Chan John, Mohan V P, Smith Issar

机构信息

The Public Health Research Institute, 225 Warren Street, Newark, NJ 07103, USA.

出版信息

Infect Immun. 2005 Jun;73(6):3754-7. doi: 10.1128/IAI.73.6.3754-3757.2005.

DOI:10.1128/IAI.73.6.3754-3757.2005
PMID:15908407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1111836/
Abstract

Using a promoter trap, we have identified 56 Mycobacterium tuberculosis genes preferentially expressed in the mouse lung. Quantitative real-time PCR showed that RNA levels of several genes were higher from bacteria growing in mouse lungs than from broth cultures. These results support the current hypothesis that Mycobacterium tuberculosis utilizes fatty acids as a carbon source in the mouse lung.

摘要

利用启动子捕获技术，我们鉴定出了56个在小鼠肺中优先表达的结核分枝杆菌基因。定量实时PCR显示，与肉汤培养物相比，小鼠肺中生长的细菌中几个基因的RNA水平更高。这些结果支持了目前的假说，即结核分枝杆菌在小鼠肺中利用脂肪酸作为碳源。