巨噬细胞移动抑制因子可抑制毒力型结核分枝杆菌在人巨噬细胞中的生长。
Macrophage migration inhibitory factor reduces the growth of virulent Mycobacterium tuberculosis in human macrophages.
作者信息
Oddo Mauro, Calandra Thierry, Bucala Richard, Meylan Pascal R A
机构信息
Medical Critical Care Division, University Hospital, CH-1011 Lausanne, Switzerland.
出版信息
Infect Immun. 2005 Jun;73(6):3783-6. doi: 10.1128/IAI.73.6.3783-3786.2005.
Abstract
Macrophage migration inhibitory factor (MIF) is a key mediator of the innate immune system and plays a crucial role in the host response to bacterial infections. Its role in immunity to intracellular pathogens has not been well studied. Here, we show that MIF released by infected human macrophages inhibits the growth of virulent Mycobacterium tuberculosis.
摘要
巨噬细胞移动抑制因子（MIF）是先天性免疫系统的关键介质，在宿主对细菌感染的反应中起关键作用。其在针对细胞内病原体的免疫中的作用尚未得到充分研究。在此，我们表明受感染的人类巨噬细胞释放的MIF可抑制强毒力结核分枝杆菌的生长。
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