来自恰加斯利什曼原虫（利什曼原虫）的重组半胱氨酸蛋白酶与人和犬的T细胞反应有关。
Recombinant cysteine proteinase from Leishmania (Leishmania) chagasi implicated in human and dog T-cell responses.
作者信息
da Costa Pinheiro Paulo Henrique, de Souza Dias Suzana, Eulálio Kelsen Dantas, Mendonça Ivete L, Katz Simone, Barbiéri Clara Lúcia
机构信息
Division of Parasitology, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Botucatu, 862-6o andar, São Paulo, SP, Brazil 04023-062.
出版信息
Infect Immun. 2005 Jun;73(6):3787-9. doi: 10.1128/IAI.73.6.3787-3789.2005.
Abstract
High in vitro lymphoproliferative responses were induced in humans and dogs by a recombinant Leishmania (Leishmania) chagasi cysteine proteinase, with secretion of IFN-gamma in asymptomatic subjects or of IFN-gamma, interleukin 4 (IL-4), and IL-10 in oligosymptomatic subjects. In contrast, responses of symptomatic patients and dogs were lower, with production of IL-4 and IL-10.
摘要
重组恰加斯利什曼原虫半胱氨酸蛋白酶在人和犬中诱导出了较高的体外淋巴细胞增殖反应，无症状受试者分泌γ干扰素，而少症状受试者分泌γ干扰素、白细胞介素4（IL-4）和白细胞介素10。相比之下，有症状患者和犬的反应较低，产生IL-4和IL-10。
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