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本文引用的文献

1
A recombinant cysteine proteinase from Leishmania (Leishmania) chagasi suitable for serodiagnosis of American visceral leishmaniasis.一种来自恰加斯利什曼原虫（利什曼原虫属）的重组半胱氨酸蛋白酶，适用于美洲内脏利什曼病的血清学诊断。
Am J Trop Med Hyg. 2005 Feb;72(2):126-32.
2
Humoral and cellular immune responses against Type I cysteine proteinase of Leishmania infantum are higher in asymptomatic than symptomatic dogs selected from a naturally infected population.从自然感染群体中挑选出的无症状犬只针对婴儿利什曼原虫I型半胱氨酸蛋白酶的体液免疫和细胞免疫反应比有症状的犬只更高。
Vet Parasitol. 2004 Jan 30;119(2-3):107-23. doi: 10.1016/j.vetpar.2003.11.013.
3
Serum cytokine profile in the subclinical form of visceral leishmaniasis.内脏利什曼病亚临床型的血清细胞因子谱
Braz J Med Biol Res. 2004 Jan;37(1):129-36. doi: 10.1590/s0100-879x2004000100018. Epub 2003 Dec 18.
4
Expression of cysteine proteinase type I and II of Leishmania infantum and their recognition by sera during canine and human visceral leishmaniasis.婴儿利什曼原虫半胱氨酸蛋白酶I和II的表达及其在犬类和人类内脏利什曼病期间被血清识别的情况。
Exp Parasitol. 2003 Mar-Apr;103(3-4):143-51. doi: 10.1016/s0014-4894(03)00097-3.
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Cytokine expression during the outcome of canine experimental infection by Leishmania infantum.婴儿利什曼原虫犬实验性感染结果期间的细胞因子表达
Vet Immunol Immunopathol. 2002 Sep 6;88(1-2):21-30. doi: 10.1016/s0165-2427(02)00134-4.
6
Inducible nitric oxide synthase and nitric oxide production in Leishmania infantum-infected human macrophages stimulated with interferon-gamma and bacterial lipopolysaccharide.γ干扰素和细菌脂多糖刺激下婴儿利什曼原虫感染的人类巨噬细胞中诱导型一氧化氮合酶及一氧化氮的产生
Int J Clin Lab Res. 1999;29(3):122-7. doi: 10.1007/s005990050076.
7
Increased levels of soluble interleukin-4 receptor in the sera of patients with visceral leishmaniasis.内脏利什曼病患者血清中可溶性白细胞介素-4受体水平升高。
J Infect Dis. 1999 Mar;179(3):743-6. doi: 10.1086/314635.
8
Molecular cloning, characterization and overexpression of two distinct cysteine protease cDNAs from Leishmania donovani chagasi.来自杜氏利什曼原虫恰加斯亚种的两个不同半胱氨酸蛋白酶cDNA的分子克隆、特性分析及过表达
Mol Biochem Parasitol. 1997 Dec 1;90(1):247-67. doi: 10.1016/s0166-6851(97)00158-8.
9
Canine visceral leishmaniasis: successful chemotherapy induces macrophage antileishmanial activity via the L-arginine nitric oxide pathway.犬内脏利什曼病：成功的化疗通过L-精氨酸一氧化氮途径诱导巨噬细胞抗利什曼原虫活性。
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10
Interleukin 10 production correlates with pathology in human Leishmania donovani infections.白细胞介素10的产生与人类杜氏利什曼原虫感染中的病理学相关。
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来自恰加斯利什曼原虫（利什曼原虫）的重组半胱氨酸蛋白酶与人和犬的T细胞反应有关。

Recombinant cysteine proteinase from Leishmania (Leishmania) chagasi implicated in human and dog T-cell responses.

作者信息

da Costa Pinheiro Paulo Henrique, de Souza Dias Suzana, Eulálio Kelsen Dantas, Mendonça Ivete L, Katz Simone, Barbiéri Clara Lúcia

机构信息

Division of Parasitology, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Botucatu, 862-6o andar, São Paulo, SP, Brazil 04023-062.

出版信息

Infect Immun. 2005 Jun;73(6):3787-9. doi: 10.1128/IAI.73.6.3787-3789.2005.

DOI:10.1128/IAI.73.6.3787-3789.2005
PMID:15908413
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1111849/
Abstract

High in vitro lymphoproliferative responses were induced in humans and dogs by a recombinant Leishmania (Leishmania) chagasi cysteine proteinase, with secretion of IFN-gamma in asymptomatic subjects or of IFN-gamma, interleukin 4 (IL-4), and IL-10 in oligosymptomatic subjects. In contrast, responses of symptomatic patients and dogs were lower, with production of IL-4 and IL-10.

摘要

重组恰加斯利什曼原虫半胱氨酸蛋白酶在人和犬中诱导出了较高的体外淋巴细胞增殖反应，无症状受试者分泌γ干扰素，而少症状受试者分泌γ干扰素、白细胞介素4（IL-4）和白细胞介素10。相比之下，有症状患者和犬的反应较低，产生IL-4和IL-10。