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Genomic Comparison of cag pathogenicity island (PAI)-positive and -negative Helicobacter pylori strains: identification of novel markers for cag PAI-positive strains.细胞毒素相关基因（cag）致病岛（PAI）阳性与阴性幽门螺杆菌菌株的基因组比较：cag致病岛阳性菌株新标志物的鉴定
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Differences in genome content among Helicobacter pylori isolates from patients with gastritis, duodenal ulcer, or gastric cancer reveal novel disease-associated genes.来自胃炎、十二指肠溃疡或胃癌患者的幽门螺杆菌分离株之间的基因组含量差异揭示了新的疾病相关基因。
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本文引用的文献

1
Distinguishing human ethnic groups by means of sequences from Helicobacter pylori: lessons from Ladakh.通过幽门螺杆菌序列区分人类族群：来自拉达克的经验教训。
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4746-51. doi: 10.1073/pnas.0306629101. Epub 2004 Mar 29.
2
Traces of human migrations in Helicobacter pylori populations.幽门螺杆菌群体中的人类迁徙痕迹。
Science. 2003 Mar 7;299(5612):1582-5. doi: 10.1126/science.1080857.
3
Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori.幽门螺杆菌抗生素耐药性的突变频率与生物学代价
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14607-12. doi: 10.1073/pnas.241517298. Epub 2001 Nov 20.
4
Identification of genes associated with natural competence in Helicobacter pylori by transposon shuttle random mutagenesis.通过转座子穿梭随机诱变鉴定幽门螺杆菌中与自然感受态相关的基因。
Biochem Biophys Res Commun. 2001 Nov 9;288(4):961-8. doi: 10.1006/bbrc.2001.5877.
5
Natural transformation competence in Helicobacter pylori is mediated by the basic components of a type IV secretion system.幽门螺杆菌的自然转化能力由IV型分泌系统的基本组件介导。
Mol Microbiol. 2001 Jul;41(2):379-91. doi: 10.1046/j.1365-2958.2001.02502.x.
6
A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains.全基因组微阵列揭示了幽门螺杆菌菌株之间的遗传多样性。
Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14668-73. doi: 10.1073/pnas.97.26.14668.
7
Mutation as an origin of genetic variability in Helicobacter pylori.突变作为幽门螺杆菌遗传变异性的一个起源。
Trends Microbiol. 1999 Dec;7(12):488-93. doi: 10.1016/s0966-842x(99)01632-7.
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Evolution of Helicobacter pylori: the role of recombination.
Trends Microbiol. 1999 May;7(5):182-4. doi: 10.1016/s0966-842x(99)01505-x.
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Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori.人类胃部病原体幽门螺杆菌两个不相关分离株的基因组序列比较。
Nature. 1999 Jan 14;397(6715):176-80. doi: 10.1038/16495.
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Free recombination within Helicobacter pylori.幽门螺杆菌内的自由重组
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细胞毒素相关基因（cag）致病岛（PAI）阳性与阴性幽门螺杆菌菌株的基因组比较：cag致病岛阳性菌株新标志物的鉴定

Genomic Comparison of cag pathogenicity island (PAI)-positive and -negative Helicobacter pylori strains: identification of novel markers for cag PAI-positive strains.

作者信息

Terry Courtney E, McGinnis Lisa M, Madigan Katharine C, Cao Ping, Cover Timothy L, Liechti George W, Peek Richard M, Forsyth Mark H

机构信息

Department of Biology, The College of William & Mary, 214 Millington Hall, Landrum Drive, Williamsburg, VA 23187-8795, USA.

出版信息

Infect Immun. 2005 Jun;73(6):3794-8. doi: 10.1128/IAI.73.6.3794-3798.2005.

DOI:10.1128/IAI.73.6.3794-3798.2005
PMID:15908415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1111835/
Abstract

In an analysis of Helicobacter pylori genomic DNA by macroarray methodology, genomic DNA from a panel of cag pathogenicity island (PAI)-negative H. pylori clinical isolates failed to hybridize with 27 genes located outside the cag PAI in a cag PAI-positive reference strain. PCR analyses confirmed that HP0217 (encoding a lipopolysaccharide biosynthetic protein) and HP1079 (encoding a protein of unknown function) were present significantly more frequently in cagA-positive strains than in cagA-negative strains. A low G+C content of these two genes suggests they were acquired by horizontal transfer events.

摘要

在用宏阵列方法分析幽门螺杆菌基因组DNA时，一组cag致病岛（PAI）阴性的幽门螺杆菌临床分离株的基因组DNA未能与cag PAI阳性参考菌株中位于cag PAI之外的27个基因杂交。PCR分析证实，HP0217（编码一种脂多糖生物合成蛋白）和HP1079（编码一种功能未知的蛋白）在cagA阳性菌株中出现的频率明显高于cagA阴性菌株。这两个基因的低G+C含量表明它们是通过水平转移事件获得的。