Reilly John J, Armstrong Julie, Dorosty Ahmad R, Emmett Pauline M, Ness A, Rogers I, Steer Colin, Sherriff Andrea
University of Glasgow Division of Developmental Medicine, Yorkhill Hospitals, Glasgow G3 8SJ.
BMJ. 2005 Jun 11;330(7504):1357. doi: 10.1136/bmj.38470.670903.E0. Epub 2005 May 20.
To identify risk factors in early life (up to 3 years of age) for obesity in children in the United Kingdom.
Prospective cohort study.
Avon longitudinal study of parents and children, United Kingdom.
8234 children in cohort aged 7 years and a subsample of 909 children (children in focus) with data on additional early growth related risk factors for obesity.
Obesity at age 7 years, defined as a body mass index (3) 95th centile relative to reference data for the UK population in 1990.
Eight of 25 putative risk factors were associated with a risk of obesity in the final models: parental obesity (both parents: adjusted odds ratio, 10.44, 95% confidence interval 5.11 to 21.32), very early (by 43 months) body mass index or adiposity rebound (15.00, 5.32 to 42.30), more than eight hours spent watching television per week at age 3 years (1.55, 1.13 to 2.12), catch-up growth (2.60, 1.09 to 6.16), standard deviation score for weight at age 8 months (3.13, 1.43 to 6.85) and 18 months (2.65, 1.25 to 5.59); weight gain in first year (1.06, 1.02 to 1.10 per 100 g increase); birth weight, per 100 g (1.05, 1.03 to 1.07); and short (< 10.5 hours) sleep duration at age 3 years (1.45, 1.10 to 1.89).
Eight factors in early life are associated with an increased risk of obesity in childhood.
确定英国儿童早期（3岁及以下）肥胖的风险因素。
前瞻性队列研究。
英国埃文亲子纵向研究。
队列中的8234名7岁儿童以及909名儿童的子样本（重点关注儿童），这些儿童有与肥胖相关的其他早期生长风险因素的数据。
7岁时的肥胖，定义为相对于1990年英国人群参考数据的体重指数（BMI）≥第95百分位数。
在最终模型中，25个假定风险因素中的8个与肥胖风险相关：父母肥胖（父母双方均肥胖：调整后的比值比为10.44，95%置信区间为5.11至21.32）、极早期（43个月前）体重指数或肥胖反弹（15.00，5.32至42.30）、3岁时每周看电视时间超过8小时（1.55，1.13至2.12）、追赶生长（2.60，1.09至6.16）、8个月时体重标准差评分（3.13，1.43至6.85）和18个月时体重标准差评分（2.65，1.25至5.59）；第一年体重增加（每增加100克为1.06，1.02至1.10）；出生体重，每100克（1.05，1.03至1.07）；以及3岁时睡眠时间短（<10.5小时）（1.45，1.10至1.89）。
早期生活中的八个因素与儿童期肥胖风险增加相关。
