Haberl A, Fischer P, Pongratz D, Sieb J P
Max-Planck-Institut für Psychiatrie, Kraepelin Strasse 10, 80804, München, Germany.
Z Rheumatol. 2005 May;64(4):274-6. doi: 10.1007/s00393-005-0576-0.
The myotoxicity of chloroquine and hydroxychloroquine has been known for decades. Limb-girdle weakness due to a vacuolar myopathy may occur occasionally in a dose-dependent manner during the first 24 months on chloroquine. However, we report on a case in which muscular weakness developed after a daily intake of 250 chloroquine phosphate (= 155 mg chloroquine base) for a period of 7 years. Even after long-term and apparently well-tolerated chloroquine treatment, the occurrence of severe side-effects is possible.
氯喹和羟氯喹的肌毒性已为人所知数十年。在使用氯喹的头24个月内，因空泡性肌病导致的肢带肌无力可能偶尔会以剂量依赖的方式出现。然而，我们报告了一例病例，该患者在每日服用250毫克磷酸氯喹（相当于155毫克氯喹碱）7年后出现了肌无力。即使经过长期且显然耐受性良好的氯喹治疗，仍有可能出现严重的副作用。
