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I型聚酮合酶可能是通过水平基因转移进化而来的。

Type I polyketide synthases may have evolved through horizontal gene transfer.

作者信息

Ginolhac Aurélien, Jarrin Cyrille, Robe Patrick, Perrière Guy, Vogel Timothy M, Simonet Pascal, Nalin Renaud

机构信息

LibraGen S.A., Bâtiment Canal Biotech 1, 3 rue des Satellites, 31400, Toulouse, France.

出版信息

J Mol Evol. 2005 Jun;60(6):716-25. doi: 10.1007/s00239-004-0161-1. Epub 2005 May 16.

DOI:10.1007/s00239-004-0161-1
PMID:15909225
Abstract

Type I polyketide synthases (PKSI) are modular multidomain enzymes involved in the biosynthesis of many natural products of industrial interest. PKSI modules are minimally organized in three domains: ketosynthase (KS), acyltransferase (AT), and acyl carrier protein. The KS domain phylogeny of 23 PKSI clusters was determined. The results obtained suggest that many horizontal transfers of PKSI genes have occurred between actinomycetales species. Such gene transfers may explain the homogeneity and the robustness of the actinomycetales group since gene transfers between closely related species could mimic patterns generated by vertical inheritance. We suggest that the linearity and instability of actinomycetales chromosomes associated with their large quantity of genetic mobile elements have favored such horizontal gene transfers.

摘要

I型聚酮合酶（PKSI）是模块化多结构域酶，参与许多具有工业价值的天然产物的生物合成。PKSI模块最少由三个结构域组成：酮合成酶（KS）、酰基转移酶（AT）和酰基载体蛋白。确定了23个PKSI基因簇的KS结构域系统发育。所得结果表明，放线菌目物种之间发生了许多PKSI基因的水平转移。这种基因转移可能解释了放线菌目群体的同质性和稳健性，因为密切相关物种之间的基因转移可能模仿垂直遗传产生的模式。我们认为，与大量遗传移动元件相关的放线菌目染色体的线性和不稳定性有利于这种水平基因转移。

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