Klont Rocus R, Eggink Cathrien A, Rijs Antonius J M M, Wesseling Pieter, Verweij Paul E
Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Clin Infect Dis. 2005 Jun 15;40(12):e110-2. doi: 10.1086/430062. Epub 2005 May 12.
A case of invasive Fusarium keratitis in a previously healthy male patient was treated successfully with cornea transplantation and systemic and topical voriconazole after treatment failure with topical amphotericin B and systemic itraconazole. Topical voriconazole was well tolerated, and, in conjunction with the oral administration, it resulted in a high level of the drug in the anterior chamber of the eye (which was 160% of the plasma drug level).
一名既往健康的男性患者发生侵袭性镰刀菌角膜炎，在局部使用两性霉素B和全身使用伊曲康唑治疗失败后，通过角膜移植以及全身和局部使用伏立康唑成功治愈。局部使用伏立康唑耐受性良好，与口服给药联合使用时，可使眼房水中药物水平升高（为血浆药物水平的160%）。
