通过角膜移植以及局部和全身应用伏立康唑成功治疗镰刀菌性角膜炎。

Successful treatment of Fusarium keratitis with cornea transplantation and topical and systemic voriconazole.

作者信息

Klont Rocus R, Eggink Cathrien A, Rijs Antonius J M M, Wesseling Pieter, Verweij Paul E

机构信息

Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

出版信息

Clin Infect Dis. 2005 Jun 15;40(12):e110-2. doi: 10.1086/430062. Epub 2005 May 12.

DOI:10.1086/430062

PMID:15909252

Abstract

A case of invasive Fusarium keratitis in a previously healthy male patient was treated successfully with cornea transplantation and systemic and topical voriconazole after treatment failure with topical amphotericin B and systemic itraconazole. Topical voriconazole was well tolerated, and, in conjunction with the oral administration, it resulted in a high level of the drug in the anterior chamber of the eye (which was 160% of the plasma drug level).

摘要

一名既往健康的男性患者发生侵袭性镰刀菌角膜炎，在局部使用两性霉素B和全身使用伊曲康唑治疗失败后，通过角膜移植以及全身和局部使用伏立康唑成功治愈。局部使用伏立康唑耐受性良好，与口服给药联合使用时，可使眼房水中药物水平升高（为血浆药物水平的160%）。