Glimcher L H, Kara C J
Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115.
Annu Rev Immunol. 1992;10:13-49. doi: 10.1146/annurev.iy.10.040192.000305.
The expression of the class-II antigens of the major histocompatibility complex is tissue-specific, developmentally regulated in cells of the B lineage, and inducible by cytokine. Some of the molecular mechanisms that account for this regulation have recently been elucidated. DNA sequences upstream of human and mouse class-II genes that are critical for the transcription of these genes have been identified through transfection studies and transgenic analysis. Furthermore, a number of transcription factors that bind to important promoter motifs have recently been isolated. Examination of the class-II promoter in vivo both in the normal state and in patients with bare lymphocyte syndrome has further increased our understanding of class-II regulation.
主要组织相容性复合体II类抗原的表达具有组织特异性，在B淋巴细胞系细胞中受发育调控，并可被细胞因子诱导。最近已经阐明了一些解释这种调控的分子机制。通过转染研究和转基因分析，已经确定了人和小鼠II类基因上游对这些基因转录至关重要的DNA序列。此外，最近分离出了一些与重要启动子基序结合的转录因子。对正常状态和裸淋巴细胞综合征患者体内II类启动子的研究进一步加深了我们对II类调控的理解。
