Hamano S, Nakanishi Y, Nara T
Division of Neurology, Saitama Childrens' Medical Center, Iwatsuki.
No To Hattatsu. 1992 May;24(3):250-6.
From September through November 1990, an outbreak of hemorrhagic colitis associated with Escherichia coli O 157: H 7, occurred in a kindergarten in Saitama, Japan. Some of the patients suffered from neurological symptoms such as stupor, deep coma and/or convulsions in the acute stage, and/or action tremors, nystagmus, incontinence, phrenic nerve palsy in the later stage. Serum complements decreased more in the patients with neurological symptoms than in the patients without them. The verotoxin elaborated by E. coli O 157: H 7 was considered to cause the neurological symptoms, on the basis of their clinical courses and laboratory findings, especially the cerebrospinal fluid findings.
1990年9月至11月期间，日本埼玉县的一所幼儿园发生了一起与大肠杆菌O157:H7相关的出血性结肠炎疫情。一些患者在急性期出现了诸如木僵、深度昏迷和/或惊厥等神经症状，和/或在后期出现动作性震颤、眼球震颤、大小便失禁、膈神经麻痹。有神经症状的患者血清补体下降幅度比没有神经症状的患者更大。根据临床病程和实验室检查结果，尤其是脑脊液检查结果，认为大肠杆菌O157:H7产生的志贺毒素导致了这些神经症状。
