Hamano S, Nakanishi Y, Nara T, Seki T, Ohtani T, Oishi T, Joh K, Oikawa T, Muramatsu Y, Ogawa Y
Division of Neurology, Saitama Children's Medical Center, Japan.
Acta Paediatr. 1993 May;82(5):454-8. doi: 10.1111/j.1651-2227.1993.tb12721.x.
An outbreak of hemorrhagic colitis associated with Escherichia coli O157:H7 occurred in a kindergarten in Saitama, Japan from September to November, 1990. Seven patients admitted to our hospital showed neurological manifestations: generalized seizures, impaired consciousness, urinary incontinence, gaze nystagmus, phrenic nerve palsy, action tremor and vertigo. Two patients died. On the basis of the clinical courses and laboratory findings of the seven patients and postmortem findings of one case, these neurological symptoms were suspected to be induced by the verotoxin elaborated by Escherichia coli O157:H7.
1990年9月至11月，日本埼玉县一所幼儿园发生了一起与大肠杆菌O157:H7相关的出血性结肠炎暴发。我院收治的7例患者出现了神经症状：全身性癫痫发作、意识障碍、尿失禁、凝视性眼球震颤、膈神经麻痹、动作性震颤和眩晕。2例患者死亡。根据这7例患者的临床病程、实验室检查结果以及1例尸检结果，怀疑这些神经症状是由大肠杆菌O157:H7产生的志贺毒素引起的。
