衰老与聚（ADP-核糖）聚合酶

Ageing and PARP.

作者信息

Bürkle Alexander, Diefenbach Jörg, Brabeck Christine, Beneke Sascha

机构信息

Molecular Toxicology Group, Box X911, University of Konstanz, D-78457 Konstanz, Germany.

出版信息

Pharmacol Res. 2005 Jul;52(1):93-9. doi: 10.1016/j.phrs.2005.02.008.

DOI:10.1016/j.phrs.2005.02.008

PMID:15911337

Abstract

Poly(ADP-ribosyl)ation, which is the posttranslational modification of proteins with poly(ADP-ribose), is catalysed by poly(ADP-ribose) polymerases. DNA-strand break induced catalytic activation of two PARP isoforms, namely PARP-1 and -2, are in involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA-damage induced poly(ADP-ribosyl)ation and mammalian longevity. This notion was reinforced by recently published evidence for interactions between PARP-1 and the Werner syndrome protein, deficiency of which causes premature ageing in humans. Recent research on PARPs and poly(ADP-ribose) provides several candidate mechanisms through which poly(ADP-ribosyl)ation might contribute to keeping the ageing process at slow pace.

摘要

聚（ADP-核糖）化是蛋白质经聚（ADP-核糖）进行的翻译后修饰，由聚（ADP-核糖）聚合酶催化。DNA链断裂诱导两种PARP亚型（即PARP-1和PARP-2）的催化激活，它们参与DNA碱基切除修复和其他修复途径。大量相关数据表明，DNA损伤诱导的聚（ADP-核糖）化与哺乳动物寿命之间存在联系。PARP-1与沃纳综合征蛋白之间相互作用的最新证据进一步强化了这一观点，该蛋白的缺乏会导致人类早衰。最近对PARP和聚（ADP-核糖）的研究提供了几种候选机制，聚（ADP-核糖）化可能通过这些机制有助于减缓衰老过程。