Beneke Sascha, Bürkle Alexander
Molecular Toxicology Group, Department of Biology, University of Konstanz, D-78457 Konstanz, Germany.
Nucleic Acids Res. 2007;35(22):7456-65. doi: 10.1093/nar/gkm735. Epub 2007 Oct 2.
Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA base-excision repair and other repair pathways. A body of correlative data suggests a link between DNA damage-induced poly(ADP-ribosyl)ation and mammalian longevity. Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through which poly(ADP-ribosyl)ation might act as a factor that limits the rate of ageing.
聚（ADP-核糖）聚合酶（PARP）催化蛋白质的聚（ADP-核糖）化翻译后修饰。两种PARP亚型，PARP-1和PARP-2，通过与DNA链断裂接触显示催化活性，并参与DNA碱基切除修复和其他修复途径。大量相关数据表明DNA损伤诱导的聚（ADP-核糖）化与哺乳动物寿命之间存在联系。最近对PARP和聚（ADP-核糖）的研究产生了几种候选机制，通过这些机制聚（ADP-核糖）化可能作为限制衰老速率的一个因素发挥作用。
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