聚（ADP - 核糖）聚合酶 -1、DNA修复与哺乳动物寿命

Poly(ADP-ribose) polymerase-1, DNA repair and mammalian longevity.

作者信息

Bürkle Alexander, Beneke Sascha, Brabeck Christine, Leake Alan, Meyer Ralph, Muiras Marie-Laure, Pfeiffer Ragen

机构信息

Department of Gerontology, Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle, NGH, Westgate Road, IHE, Newcastle upon Tyne NE4 6BE, UK.

出版信息

Exp Gerontol. 2002 Oct-Nov;37(10-11):1203-5. doi: 10.1016/s0531-5565(02)00144-4.

DOI:10.1016/s0531-5565(02)00144-4

PMID:12470832

Abstract

Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally associated with DNA base-excision repair and strand break repair. Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span.

摘要

细胞DNA修复活性有望通过将DNA损伤的稳态水平维持在较低水平来控制衰老过程的速率，DNA损伤是由内源性和外源性损伤剂持续诱导产生的。聚（ADP-核糖）化是真核细胞对DNA损伤的即时生化反应之一，在功能上与DNA碱基切除修复和链断裂修复相关。在这里，我们综述了有关DNA链断裂修复、聚（ADP-核糖）化、基因组稳定性维持与哺乳动物寿命之间关系的当前研究现状。