Bürkle Alexander, Beneke Sascha, Brabeck Christine, Leake Alan, Meyer Ralph, Muiras Marie-Laure, Pfeiffer Ragen
Department of Gerontology, Institute for Ageing and Health, Wolfson Research Centre, University of Newcastle, NGH, Westgate Road, IHE, Newcastle upon Tyne NE4 6BE, UK.
Exp Gerontol. 2002 Oct-Nov;37(10-11):1203-5. doi: 10.1016/s0531-5565(02)00144-4.
Cellular DNA repair activities can be expected to control the rate of the ageing process by keeping the steady-state levels of DNA damage, which is continuously induced by endogenous and exogenous damaging agents, at low levels. Poly(ADP-ribosyl)ation is one of the immediate biochemical reactions of eukaryotic cells to DNA damage and is functionally associated with DNA base-excision repair and strand break repair. Here we review the current state of the art concerning the relationship between DNA strand break repair, poly(ADP-ribosyl)ation, maintenance of genomic stability and mammalian life span.
细胞DNA修复活性有望通过将DNA损伤的稳态水平维持在较低水平来控制衰老过程的速率，DNA损伤是由内源性和外源性损伤剂持续诱导产生的。聚（ADP-核糖）化是真核细胞对DNA损伤的即时生化反应之一，在功能上与DNA碱基切除修复和链断裂修复相关。在这里，我们综述了有关DNA链断裂修复、聚（ADP-核糖）化、基因组稳定性维持与哺乳动物寿命之间关系的当前研究现状。
