单一纯合基因型的哈迪-温伯格检验
Hardy-Weinberg testing of a single homozygous genotype.
作者信息
Chen John J, Duan Tao, Single Richard, Mather Kristie, Thomson Glenys
机构信息
Department of Preventive Medicine, State University of New York, Stony Brook, New York 11794, USA.
出版信息
Genetics. 2005 Jul;170(3):1439-42. doi: 10.1534/genetics.105.043190. Epub 2005 May 23.
Abstract
No proper statistical test is available for the evaluation of deviation of a single homozygous genotype from Hardy-Weinberg equilibrium (HWE) proportion. We propose a 1-d.f. chi2-test. The power of the proposed test is favorable compared to existing HWE testing procedures. The applications of this test are discussed.
摘要
没有合适的统计检验可用于评估单个纯合基因型与哈迪-温伯格平衡（HWE）比例的偏差。我们提出了一种自由度为1的卡方检验。与现有的HWE检验程序相比，所提出检验的功效良好。本文讨论了该检验的应用。
相似文献
1
Hardy-Weinberg testing of a single homozygous genotype.单一纯合基因型的哈迪-温伯格检验
Genetics. 2005 Jul;170(3):1439-42. doi: 10.1534/genetics.105.043190. Epub 2005 May 23.
2
A test of Hardy-Weinberg equilibrium in structured populations.在结构群体中进行 Hardy-Weinberg 平衡检验。
Genet Epidemiol. 2011 Nov;35(7):671-8. doi: 10.1002/gepi.20617. Epub 2011 Aug 4.
3
Power divergence test statistics for testing Hardy-Weinberg equilibrium.用于检验哈迪-温伯格平衡的幂散度检验统计量。
J Genet. 2019 Jun;98(2).
4
Calculation and use of the Hardy-Weinberg model in association studies.哈迪-温伯格模型在关联研究中的计算与应用。
Curr Protoc Hum Genet. 2008 Apr;Chapter 1:Unit 1.18. doi: 10.1002/0471142905.hg0118s57.
5
[Application of chi-square test and exact test in Hardy-Weinberg equilibrium testing].[卡方检验和确切检验在哈迪-温伯格平衡检验中的应用]
Fa Yi Xue Za Zhi. 2004;20(2):116-9.
6
Adapting the logical basis of tests for Hardy-Weinberg Equilibrium to the real needs of association studies in human and medical genetics.使 Hardy-Weinberg 平衡检验的逻辑基础适应人类和医学遗传学关联研究的实际需要。
Genet Epidemiol. 2009 Nov;33(7):569-80. doi: 10.1002/gepi.20409.
7
A note on exact tests of Hardy-Weinberg equilibrium.关于哈迪-温伯格平衡精确检验的一则注释。
Am J Hum Genet. 2005 May;76(5):887-93. doi: 10.1086/429864. Epub 2005 Mar 23.
8
Hardy-Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power.遗传关联研究中的哈迪-温伯格平衡：报告、偏差及效能的实证评估
Eur J Hum Genet. 2005 Jul;13(7):840-8. doi: 10.1038/sj.ejhg.5201410.
9
A new method of testing for Hardy-Weinberg equilibrium and ordering populations.一种检验哈迪-温伯格平衡和对群体进行排序的新方法。
J Genet. 2007 Apr;86(1):1-7. doi: 10.1007/s12041-007-0001-3.
10
Testing Departure from Hardy-Weinberg Proportions.检验偏离哈迪-温伯格平衡比例的情况。
Methods Mol Biol. 2017;1666:83-115. doi: 10.1007/978-1-4939-7274-6_6.
引用本文的文献
1
The risk of new-onset cancer associated with HFE C282Y and H63D mutations: evidence from 87,028 participants.与HFE基因C282Y和H63D突变相关的新发癌症风险：来自87,028名参与者的证据。
J Cell Mol Med. 2016 Jul;20(7):1219-33. doi: 10.1111/jcmm.12764. Epub 2016 Feb 19.
2
A heterozygote-homozygote test of Hardy-Weinberg equilibrium.杂合子-纯合子 Hardy-Weinberg 平衡检验。
Eur J Hum Genet. 2009 Nov;17(11):1495-500. doi: 10.1038/ejhg.2009.57. Epub 2009 Apr 15.
3
Detecting selection-induced departures from Hardy-Weinberg proportions.检测选择导致的偏离哈迪-温伯格平衡比例的情况。
Genet Sel Evol. 2009 Jan 21;41(1):15. doi: 10.1186/1297-9686-41-15.
4
Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence.两种μ-阿片受体基因（OPRM1）单倍型模块与药物或酒精依赖之间的关联。
Hum Mol Genet. 2006 Mar 15;15(6):807-19. doi: 10.1093/hmg/ddl024. Epub 2006 Feb 13.
本文引用的文献
1
A comparison of tests for Hardy-Weinberg equilibrium.哈迪-温伯格平衡检验方法的比较。
Biometrics. 1980 Dec;36(4):627-42.
2
Detection of errors in dinucleotide repeat typing by nondenaturing electrophoresis.通过非变性电泳检测二核苷酸重复序列分型中的错误
Electrophoresis. 2001 Aug;22(13):2656-64. doi: 10.1002/1522-2683(200108)22:13<2656::AID-ELPS2656>3.0.CO;2-6.
3
The variance for the disequilibrium coefficient in the individual Hardy-Weinberg test.个体哈迪-温伯格检验中不平衡系数的方差。
Biometrics. 1999 Dec;55(4):1269-72. doi: 10.1111/j.0006-341x.1999.01269.x.
4
Hardy-Weinberg quality control.哈迪-温伯格平衡质量控制
Ann Hum Genet. 1999 Nov;63(Pt 6):535-8. doi: 10.1017/S0003480099007824.
5
Heterogeneous mutation processes in human microsatellite DNA sequences.人类微卫星DNA序列中的异质突变过程。
Nat Genet. 2000 Apr;24(4):400-2. doi: 10.1038/74249.
6
Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups.对26个人类族群的HLA II类（DRB1、DQA1、DQB1和DPB1）基因座进行哈迪-温伯格检验。
Tissue Antigens. 1999 Dec;54(6):533-42. doi: 10.1034/j.1399-0039.1999.540601.x.
7
HLA DQ alpha genotype and allele frequencies in Qatari population.卡塔尔人群中的HLA DQα基因型和等位基因频率。
Forensic Sci Int. 1997 Nov 10;90(1-2):11-5. doi: 10.1016/s0379-0738(97)00132-1.
8
Characterization of 12 microsatellite loci of the human MHC in a panel of reference cell lines.一组参考细胞系中人类主要组织相容性复合体12个微卫星位点的特征分析。
Immunogenetics. 1998;47(2):131-8. doi: 10.1007/s002510050338.
9
Enhanced PCR amplification of VNTR locus D1S80 using peptide nucleic acid (PNA).使用肽核酸（PNA）增强VNTR基因座D1S80的PCR扩增。
Nucleic Acids Res. 1995 Aug 11;23(15):3050-5. doi: 10.1093/nar/23.15.3050.
10
Chi-squared tests with small numbers.
Ann Hum Genet. 1986 May;50(2):163-7. doi: 10.1111/j.1469-1809.1986.tb01035.x.
Zotero 插件