[一种使用胶原蛋白与核黄素/紫外线A光交联治疗准分子激光原位角膜磨镶术后角膜扩张症的新方法]
[A new treatment of keratectasia after LASIK by using collagen with riboflavin/UVA light cross-linking].
作者信息
Kohlhaas M, Spoerl E, Speck A, Schilde T, Sandner D, Pillunat L E
机构信息
Universitäts-Augenklinik Carl Gustav Carus, Dresden.
出版信息
Klin Monbl Augenheilkd. 2005 May;222(5):430-6. doi: 10.1055/s-2005-857950.
BACKGROUND
Keratectasia is one of the most severe complications after refractive laser surgery. Usually penetrating keratoplasty is the treatment of choice to achieve an optical rehabilitation in such cases.
PATIENTS AND METHODS
We report on a female patient who developed keratectasia in both eyes 4 weeks after LASIK. Due to a severe keratectasia 10 months after LASIK, a treatment with riboflavin/UVA cross-linking was performed.
RESULTS
Due to the induced collagen cross-linking the biomechanical status of the cornea was stabilized and a progression of the keratectasia was prevented. The postoperative refraction and corneal topography have been stable for 18 months.
CONCLUSION
Collagen cross-linking leads to a stiffening of the anterior parts of the corneal stroma. The increase of biomechanical stability can stop the progression of a keratectasia after LASIK by means of a simple procedure.
背景
角膜扩张是屈光性激光手术后最严重的并发症之一。在这种情况下，穿透性角膜移植术通常是实现视力康复的首选治疗方法。
患者与方法
我们报告一名女性患者，她在LASIK术后4周双眼出现角膜扩张。由于LASIK术后10个月出现严重角膜扩张，进行了核黄素/紫外线A交联治疗。
结果
由于诱导的胶原交联，角膜的生物力学状态得以稳定，角膜扩张的进展得到预防。术后屈光和角膜地形图在18个月内一直稳定。
结论
胶原交联导致角膜基质前部变硬。生物力学稳定性的提高可以通过一个简单的程序阻止LASIK术后角膜扩张的进展。
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