Boyle C A, Khoury M J, Katz D F, Annest J L, Kresnow M J, DeStefano F, Schrader S M
Division of Birth Defects and Developmental Disabilities, Centers for Disease Control, Atlanta, GA 30333.
Epidemiology. 1992 May;3(3):239-46. doi: 10.1097/00001648-199205000-00009.
We investigated the relation between various sperm characteristics, including morphometric parameters, and impaired fertility among 596 men who participated in a national study. Semen was collected and processed by using a standardized protocol, and sperm measurements were made using a computer-aided sperm analysis instrument. We defined infertility in two ways: (1) the inability to father a child after trying for a year or longer, and (2) the number of children fathered. We found that all measures of sperm motion were decreased among men with impaired fertility. After adjustment for the other motion parameters and various potential confounders, however, only the percentage of progressive cells was associated with infertility. One morphometric parameter, the mean length/width ratio, was consistently associated with both measures of infertility, even after adjustment for potential covariates. This measure was also strongly associated with infertility among various subgroups defined by poor sperm concentration, motility, and morphology. The sperm length/width ratio appears to be an important correlate of infertility in males.
我们在参与一项全国性研究的596名男性中，调查了包括形态学参数在内的各种精子特征与生育能力受损之间的关系。精液采用标准化方案采集和处理，精子测量使用计算机辅助精子分析仪进行。我们以两种方式定义不育：（1）尝试一年或更长时间后仍无法使配偶受孕，（2）已育子女数量。我们发现，生育能力受损男性的所有精子运动指标均下降。然而，在对其他运动参数和各种潜在混杂因素进行调整后，只有进行性运动细胞的百分比与不育相关。一个形态学参数，即平均长宽比，即使在对潜在协变量进行调整后，也始终与两种不育指标相关。在由精子浓度低、活力差和形态异常定义的各种亚组中，该指标也与不育密切相关。精子长宽比似乎是男性不育的一个重要相关因素。
