Khandwala Yash S, Zhang Chiyuan A, Li Shufeng, Behr Barry, Guo David, Eisenberg Michael L
Department of Urology, Stanford University School of Medicine, Stanford, CA; University of California San Diego School of Medicine, La Jolla, CA.
Department of Urology, Stanford University School of Medicine, Stanford, CA.
Urology. 2017 Aug;106:96-102. doi: 10.1016/j.urology.2017.03.064. Epub 2017 May 15.
To identify racial differences in semen quality among men living in the same geographic area and seeking fertility evaluation.
Men obtaining a semen analysis for infertility evaluation or treatment between 2012 and 2016 at a single center were identified, and demographic data including height, weight, body mass index (BMI), and age were described. Mean semen parameters and the proportions of men with suboptimal parameters based on the World Health Organization's fifth edition criteria were also compared based on race. Multivariable regression analysis was conducted incorporating age, BMI, and year of evaluation. Further subanalyses based on BMI were subsequently performed.
White men produced greater volumes of semen on average; however, Asian men had higher sperm concentrations and total sperm count. A lower proportion of Asian men compared to white men had semen quality in the suboptimal range for most semen parameters, whereas a higher proportion of white men were found to have azoospermia. Stratification by BMI groups attenuated the observed differences between whites and Asians, yet Asian male semen quality remained higher.
Among men evaluated for infertility at a single center, Asians had lower volume but higher sperm concentrations compared with whites, which was influenced by differences in azoospermia prevalence. Although anthropometric and demographic factors attenuated the differences, even after adjustment, the contrasts remained. Our study suggests that racial differences exist in semen quality at the time of infertility evaluation.
确定居住在同一地理区域且寻求生育力评估的男性精液质量的种族差异。
确定2012年至2016年期间在单一中心进行不育评估或治疗而接受精液分析的男性，并描述其人口统计学数据，包括身高、体重、体重指数（BMI）和年龄。还根据种族比较了平均精液参数以及根据世界卫生组织第五版标准精液参数欠佳的男性比例。进行了纳入年龄、BMI和评估年份的多变量回归分析。随后基于BMI进行了进一步的亚组分析。
白人男性平均精液量更大；然而，亚洲男性的精子浓度和总精子数更高。与白人男性相比，亚洲男性中大多数精液参数处于欠佳范围的比例较低，而白人男性中无精子症的比例较高。按BMI分组分层减弱了观察到的白人和亚洲人之间的差异，但亚洲男性的精液质量仍然较高。
在单一中心接受不育评估的男性中，与白人相比，亚洲男性的精液量较低，但精子浓度较高，这受到无精子症患病率差异的影响。尽管人体测量和人口统计学因素减弱了差异，但即使经过调整，差异仍然存在。我们的研究表明，在不育评估时精液质量存在种族差异。
