Gurkan Mehmet, Arikan Sevket, Ozaytekin Ebru, Dodurka Tamer
Department of Surgery, Faculty of Veterinary Medicine, Kirikkale University, Kirikkale, Turkey.
J Feline Med Surg. 2005 Oct;7(5):301-5. doi: 10.1016/j.jfms.2005.03.003.
The severity of a transfusion reaction depends on alloantibody titres within the recipients' blood. Determination of an agglutination titre of naturally occurring alloantibody may help to assess the risk of transfusion reactions following an unmatched transfusion in a cat population. In this group of 312 cats 227 had blood type A, 78 had blood type B, and seven had type AB blood. All type B cats tested showed gross evidence of agglutinating anti-A antibody with plasma titres ranging from 2 to 256. Among the 227 type A domestic cats tested for plasma anti-B alloantibody titres, 70% had gross agglutination with titres ranging from 2 to 16, while 17.6% had microscopic agglutination. The remaining 12.4% of the type A cats were negative for both gross and microscopic agglutination. Based on agglutinating titres, the relative risk of a transfusion reaction when type A or AB blood was given to a type B cat was 6.4% with acute severe reaction, acute mild reactions in 85.9% and premature red cell destruction in 7.7%. On the other hand, transfusion of type AB blood or type B blood to type A cats carries a potential risk of acute mild transfusion reaction in 4.4% and premature red cell destruction in 83.3%. Transfusion of type A or B blood to type AB cats results in no apparent clinical transfusion reactions.
输血反应的严重程度取决于受血者血液中的同种抗体滴度。测定天然存在的同种抗体的凝集滴度可能有助于评估猫群中不匹配输血后发生输血反应的风险。在这组312只猫中，227只为A型血，78只为B型血，7只为AB型血。所有检测的B型猫均显示出明显的抗A凝集抗体，血浆滴度范围为2至256。在检测血浆抗B同种抗体滴度的227只A型家猫中，70%有明显凝集，滴度范围为2至16，而17.6%有显微镜下凝集。其余12.4%的A型猫在肉眼和显微镜下凝集均为阴性。根据凝集滴度，当给B型猫输注A型或AB型血时，发生输血反应的相对风险为：急性严重反应为6.4%，急性轻度反应为85.9%，红细胞过早破坏为7.7%。另一方面，给A型猫输注AB型血或B型血有4.4%发生急性轻度输血反应的潜在风险，83.3%发生红细胞过早破坏的潜在风险。给AB型猫输注A型或B型血不会导致明显的临床输血反应。
