McDermott Fergal M, Maloney Stephanie, McMillan Chantal, Snead Elisabeth
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Department of Veterinary Clinical and Diagnostic Science, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada.
Front Vet Sci. 2020 Apr 21;7:160. doi: 10.3389/fvets.2020.00160. eCollection 2020.
The purpose of this study was to evaluate blood types of domestic cats in two cities in Western Canada (Saskatoon, Saskatchewan and Calgary, Alberta), as well as to determine the risk of mismatched transfusion and neonatal isoerythrolysis. Several cat studies around the world have shown variability in the prevalence of blood types in domestic and pedigree cats. Canadian data based on feline blood types is based out of Montreal. In this study the cohort of cats revealed a higher than anticipated prevalence; of 5% type B and 0.6% AB blood types. In our study, blood typing was performed in 400 domestic cats; 200 in Saskatoon and 200 in Calgary. Blood typing was performed using the gel tube method and the risk of transfusion mismatch (MT) was estimated by adding the risk of a major transfusion reaction and the risk of a minor transfusion reaction. The risk of neonatal isoerythrolysis (NI) was estimated according to the equation (p)(q) + 2pq(q), with q being the b allele frequency and = 1 - q. There was an identical frequency for feline blood types in both Saskatoon and Calgary cats, with 96% type A, 4% type B, and 0% AB. Based on these percentages, the risks of MT and NI in domestic cats were 7.6 and 4 % respectively. The frequency of type B cats in the population was similar to that in the previous Canadian study. These results demonstrate regional differences in prevalence of type B blood in domestic shorthairs across the world and serve to reinforce recommendations to blood type prior to transfusion or mating.
本研究的目的是评估加拿大西部两个城市（萨斯喀彻温省萨斯卡通市和艾伯塔省卡尔加里市）家猫的血型，并确定输血不匹配和新生儿溶血病的风险。世界各地的多项猫类研究表明，家猫和纯种猫的血型患病率存在差异。基于猫血型的加拿大数据来自蒙特利尔。在本研究中，猫群显示出高于预期的患病率；B型血占5%，AB型血占0.6%。在我们的研究中，对400只家猫进行了血型鉴定；其中200只来自萨斯卡通市，200只来自卡尔加里市。采用凝胶管法进行血型鉴定，并通过将主要输血反应风险和次要输血反应风险相加来估计输血不匹配（MT）的风险。根据公式（p）（q）+2pq（q）估计新生儿溶血病（NI）的风险，其中q为b等位基因频率，p = 1 - q。萨斯卡通市和卡尔加里市的猫的血型频率相同，A型血占96%，B型血占4%，AB型血占0%。根据这些百分比，家猫中MT和NI的风险分别为7.6%和4%。猫群中B型猫的频率与之前的加拿大研究相似。这些结果表明了世界各地家养短毛猫中B型血患病率的区域差异，并有助于强化在输血或交配前进行血型鉴定的建议。
