Richter Bettina W M, Onuska Jaya M, Niewiesk Stefan, Prince Gregory A, Eichelberger Maryna C
Virion Systems, Inc., Rockville, MD 20850-3347, USA.
Virology. 2005 Jun 20;337(1):102-10. doi: 10.1016/j.virol.2005.04.001.
Respiratory syncytial virus (RSV) is a major cause of lower airway disease in infants and children. Immunity to RSV is not long lasting, resulting in re-occurring infections throughout life. Effective long-lived immunity results when central-memory T cells that proliferate vigorously and secrete IL-2 are present. In contrast, effector-memory T cells that mainly produce IFN-gamma, facilitate virus clearance but are not long lived. To identify the type of memory response induced after RSV-A (Long) infection, we characterized the kinetics of the antigen-specific immune response and identified the types of cytokines induced. RSV-specific lymphocytic proliferation following primary and secondary infection was similar, and in both cases responses waned within a short period of time. In addition, mRNA for IFN-gamma but not IL-2 was induced in RSV-specific CD4(+) T cells. This supports the idea that the presence of effector-memory rather than central-memory T cells contributes to the ineffectiveness of the immune response to RSV.
呼吸道合胞病毒（RSV）是婴幼儿下呼吸道疾病的主要病因。对RSV的免疫力不会持久，导致一生中反复感染。当存在大量增殖并分泌白细胞介素-2的中枢记忆T细胞时，会产生有效的长期免疫力。相比之下，主要产生干扰素-γ的效应记忆T细胞有助于病毒清除，但寿命不长。为了确定RSV-A（长株）感染后诱导的记忆反应类型，我们对抗原特异性免疫反应的动力学进行了表征，并确定了诱导的细胞因子类型。初次和二次感染后RSV特异性淋巴细胞增殖相似，且在两种情况下反应均在短时间内减弱。此外，RSV特异性CD4(+) T细胞中诱导产生了干扰素-γ的信使核糖核酸，但未诱导产生白细胞介素-2的信使核糖核酸。这支持了以下观点，即效应记忆T细胞而非中枢记忆T细胞的存在导致了对RSV免疫反应的无效性。
