猴腺病毒1型全基因组序列：一种具有两个纤维基因的旧世界猴腺病毒

Complete genome sequence of simian adenovirus 1: an Old World monkey adenovirus with two fiber genes.

作者信息

Kovács Gábor M, Harrach Balázs, Zakhartchouk Alexander N, Davison Andrew J

机构信息

Veterinary Medical Research Institute, Hungarian Academy of Sciences, PO Box 18, H-1581 Budapest, Hungary.

Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3.

出版信息

J Gen Virol. 2005 Jun;86(Pt 6):1681-1686. doi: 10.1099/vir.0.80757-0.

DOI:10.1099/vir.0.80757-0

PMID:15914845

Abstract

Simian adenovirus 1 (SAdV-1) is one of many adenovirus strains that were isolated from Old World monkey cells during poliomyelitis vaccine production several decades ago. Despite the availability of these viruses, knowledge of their genetic content and phylogeny is rudimentary. In the present study, the genome sequence of SAdV-1 (34,450 bp) was determined and analysed. In regions where genetic content varies between primate adenoviruses, SAdV-1 has a single virus-associated RNA gene, six genes in each of the E3 and E4 regions and two fiber genes. SAdV-1 clusters phylogenetically with HAdV-40, a member of human adenovirus species HAdV-F, which also has two fiber genes. However, based on phylogenetic distances and other taxonomic criteria, SAdV-1 is proposed to represent a novel adenovirus species.

摘要

猿猴腺病毒1型（SAdV-1）是几十年前在脊髓灰质炎疫苗生产过程中从旧世界猴细胞中分离出的众多腺病毒株之一。尽管有这些病毒，但对其遗传内容和系统发育的了解仍很初步。在本研究中，测定并分析了SAdV-1的基因组序列（34,450 bp）。在灵长类腺病毒之间遗传内容不同的区域，SAdV-1有一个单一的病毒相关RNA基因、E3和E4区域各有六个基因以及两个纤维基因。SAdV-1在系统发育上与人类腺病毒物种HAdV-F的成员HAdV-40聚类，HAdV-40也有两个纤维基因。然而，基于系统发育距离和其他分类标准，SAdV-1被提议代表一种新型腺病毒物种。