Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Emerg Infect Dis. 2012 Jul;18(7):1081-8. doi: 10.3201/eid1807.111665.
Adenoviruses can cause infectious diarrheal disease or respiratory infections in humans; 2 recent reports have indicated probable human infection with simian adenoviruses (SAdVs). To assess the possibility of animal-to-human transmission of SAdVs, we tested fecal samples from asymptomatic rhesus macaques housed in 5 primate facilities in the United States and cultured 23 SAdV isolates. Of these, 9 were purified and completely sequenced; 3 SAdV samples from the American Type Culture Collection (SAdV-6, SAdV-18, and SAdV-20) were also completely sequenced. The sequence of SAdV-18 was closely related to that of human adenovirus F across the whole genome, and the new isolates were found to harbor 2 fiber genes similar to those of human adenovirus (HAdV) strains HAdV-40 and HAdV-41, which can cause infectious diarrhea. The high prevalence of adenoviruses in fecal samples from asymptomatic rhesus macaques and the similarity of the isolates to human strains indicates the possibility of animal-to-human transmission of SAdVs.
腺病毒可引起人类感染性腹泻病或呼吸道感染；最近有 2 份报告表明，可能有人感染了猿猴腺病毒（SAdV）。为评估 SAdV 由动物传染给人类的可能性，我们检测了美国 5 个灵长类动物设施中无症状恒河猴的粪便样本，并培养了 23 株 SAdV 分离株。其中 9 株被纯化并完成了全序列测序；美国典型培养物保藏中心的 3 株 SAdV 样本（SAdV-6、SAdV-18 和 SAdV-20）也完成了全序列测序。SAdV-18 的序列与整个基因组中的人腺病毒 F 密切相关，新分离株的纤维 2 基因与可引起感染性腹泻的人腺病毒（HAdV）株 HAdV-40 和 HAdV-41 相似。无症状恒河猴粪便样本中腺病毒的高流行率以及分离株与人株的相似性表明，SAdV 可能由动物传染给人类。
