Koo Peter J S
Pain Management, Department of Clinical Pharmacy and Pharmaceutical Services, School of Pharmacy, University of California, San Francisco, C-152, Box 062, 521 Parnassus Avenue, San Francisco, CA 94143-0622, USA.
Am J Health Syst Pharm. 2005 Jun 1;62(11):1171-6. doi: 10.1093/ajhp/62.11.1171.
The efficacy and safety of fentanyl hydrochloride patient-controlled trans-dermal system (PCTS) for management of acute postoperative pain are discussed.
Fentanyl hydrochloride PCTS is a self-contained, needle-free, credit-card-sized fentanyl-delivery system that is worn on the patient's arm or chest. The system uses iontophoretic technology to actively deliver preprogrammed doses of fentanyl into the systemic circulation when activated by the patient on demand. PCTS is as safe and effective as i.v. morphine patient-controlled analgesia and superior to placebo for managing acute postoperative pain. Fentanyl absorption from PCTS is clinically insignificant when the device is not activated. This contrasts with the transdermal fentanyl patch, which delivers fentanyl continuously for 72 hours via passive absorption and is indicated only for use in the management of chronic pain.
Fentanyl hydrochloride PCTS is a self-contained iontophoretic fentanyl-delivery system that provides patients control over pain management and consistent management of pain without analgesic peaks and troughs.
探讨盐酸芬太尼患者自控透皮系统（PCTS）用于术后急性疼痛管理的有效性和安全性。
盐酸芬太尼PCTS是一种独立的、无需针头、信用卡大小的芬太尼给药系统，可佩戴在患者手臂或胸部。该系统采用离子电渗技术，在患者按需激活时，将预先设定剂量的芬太尼主动输送到体循环中。PCTS在管理术后急性疼痛方面与静脉注射吗啡患者自控镇痛一样安全有效，且优于安慰剂。当设备未激活时，PCTS的芬太尼吸收在临床上无显著意义。这与透皮芬太尼贴剂形成对比，后者通过被动吸收持续释放芬太尼72小时，仅适用于慢性疼痛的管理。
盐酸芬太尼PCTS是一种独立的离子电渗芬太尼给药系统，可让患者自主控制疼痛管理，并持续稳定地管理疼痛，无镇痛峰谷现象。
