Chelly Jacques E
Department of Anesthesiology, UPMC Shadyside Hospital, Posner Pain Center, 5230 Centre Avenue, Pittsburgh, PA 15232, USA.
Expert Opin Pharmacother. 2005 Jun;6(7):1205-14. doi: 10.1517/14656566.6.7.1205.
Patient-controlled modalities using intravenous or epidural routes have dramatically improved postoperative pain management. However, acute post-operative pain continues to be undermanaged. Intravenous patient-controlled analgesia (PCA), the current standard of care for acute postoperative pain management, requires the patient to be attached to a staff-programmed pump apparatus via an intravenous catheter and tubing, rendering it invasive and mobility-limiting. An innovative, needle-free, iontophoretic, fentanyl HCl patient-controlled transdermal system (PCTS) is being developed for acute postoperative pain management. Fentanyl HCl PCTS is a compact, self-contained system that is easily applied to the upper outer arm or chest. It provides pain relief therapeutically equivalent to that of a standard regimen of morphine intravenous PCA, with pharmacokinetics similar to those of intravenous fentanyl infusion. Fentanyl HCl PCTS may be an effective, non-invasive alternative to currently available PCA modalities.
采用静脉或硬膜外途径的患者自控模式显著改善了术后疼痛管理。然而，术后急性疼痛仍未得到充分管理。静脉自控镇痛（PCA）是目前术后急性疼痛管理的护理标准，它要求患者通过静脉导管和输液管连接到由医护人员编程的泵装置上，这使其具有侵入性且限制了患者的活动能力。一种创新的、无针的、离子电渗的盐酸芬太尼患者自控透皮系统（PCTS）正在被开发用于术后急性疼痛管理。盐酸芬太尼PCTS是一个紧凑的、独立的系统，易于应用于上臂外侧或胸部。它提供的疼痛缓解效果在治疗上等同于吗啡静脉PCA的标准方案，其药代动力学与静脉注射芬太尼输注相似。盐酸芬太尼PCTS可能是目前可用PCA模式的一种有效的、非侵入性替代方案。
