Skledar Susan J, Lachell Carsten M, Chelly Jacques E
a Department of Pharmacy & Therapeutics , University of Pittsburgh School of Pharmacy , Pittsburgh , PA 15213 , USA.
b Health System Formulary Management and Drug Use Policy, Department of Pharmacy , University of Pittsburgh Medical Center (UPMC), Medical Arts Building , Suite 300, 3708 Fifth Avenue, Pittsburgh , PA 15213 , USA.
Expert Opin Drug Metab Toxicol. 2015;11(12):1925-35. doi: 10.1517/17425255.2015.1112788. Epub 2015 Nov 13.
The fentanyl iontophoretic transdermal system (ITS) is a patient-controlled transdermal system allowing needle-free administration of on-demand doses of Fentanyl of 40 µg over a 10-min period up to 80 doses or over a 24-h period. It is indicated in opioid naïve patients for the treatment of acute postoperative pain in the hospitalized patients for up to 72 h.
It has been demonstrated to be effective and safe in randomized trials and to provide comparable analgesia versus morphine intravenous (i.v.) patient-controlled analgesia (PCA) with adverse events similar between groups.
Fentanyl ITS has shown high patient satisfaction rates, and was described by patients and investigators as easy and convenient to use. These properties make this technology interesting when considering perioperative pain management. In the present health care environment additional data are required to establish the cost-benefit ratio of this technology in optimizing patient's recovery from surgery.
芬太尼离子导入透皮系统（ITS）是一种患者自控透皮系统，可在10分钟内无针按需给药40μg芬太尼，最多可给药80剂，或在24小时内给药。它适用于初次使用阿片类药物的患者，用于治疗住院患者的急性术后疼痛，最长可达72小时。
在随机试验中已证明其有效且安全，与吗啡静脉自控镇痛（PCA）相比，能提供相当的镇痛效果，两组不良事件相似。
芬太尼ITS显示出较高的患者满意度，患者和研究者均称其使用简便。考虑围手术期疼痛管理时，这些特性使该技术颇具吸引力。在当前的医疗环境下，需要更多数据来确定该技术在优化患者术后恢复方面的成本效益比。
