Palma-Carlos A G, Palma-Carlos M L
Clinical Allergy Immunology Center, Lisbon, Portugal.
Eur Ann Allergy Clin Immunol. 2005 Apr;37(4):143-6.
Purpose was to evaluate thyroid auto-immunity and thyroid function in chronic urticaria (CU). Evaluation of antibodies Ab to thyroglobulin (TG) thyroid peroxidase (TPO) and of TSH, FT3, FT4, and of intra-dermal self test with patients own serum in 56 patients presenting chronic idiopathic urticaria and in a matched control group of 56 subjects without CU. Ab to TG positive in 13 (22.2%) to TPO in 15 (26.8%). Overall thyroid antibodies 28.5%. Thyroid function normal in 52 patients, TSH increased in 2, FT3 decreased in 1, TG and TPO Abs and thyroid function results always normal in control group. Self test positive in 4 out of 56 patients. Therapy with thyroid extract was effective in 2 out of 5 cases. CU is associated with thyroid autoimmunity in most cases. Thyroid Ab and function must be evaluated in all the cases of chronic urticaria.
目的是评估慢性荨麻疹（CU）患者的甲状腺自身免疫和甲状腺功能。对56例慢性特发性荨麻疹患者及56例与之匹配的无慢性荨麻疹对照组进行甲状腺球蛋白（TG）、甲状腺过氧化物酶（TPO）抗体以及促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）的评估，并采用患者自身血清进行皮内自身试验。13例（22.2%）TG抗体阳性，15例（26.8%）TPO抗体阳性。总体甲状腺抗体阳性率为28.5%。52例患者甲状腺功能正常，2例TSH升高，1例FT3降低，对照组中TG和TPO抗体及甲状腺功能结果均正常。56例患者中有4例皮内自身试验阳性。5例患者中2例使用甲状腺提取物治疗有效。大多数情况下，慢性荨麻疹与甲状腺自身免疫相关。所有慢性荨麻疹病例均须评估甲状腺抗体和功能。
