Fernandez Romero Diego S, Malbran Alejandro
Alergia e Inmunología Cĺinica, Hospital Británico de Buenos Aires.
Medicina (B Aires). 2005;65(3):231-4.
Chronic urticaria is a frequent pathology, characterized by the presence of hives and/or angioedema lasting longer than 6 weeks. In an important number of patients it behaves as an autoimmune illness, frequently associated with alterations in thyroid function and thyroid antibodies. We herein describe a consecutive series of 70 patients with a diagnosis of chronic urticaria. Seven (10%) had a diagnosis of thyroid illness previous to their first consultation. Thyroid function and thyroid antibodies were studied in the remaining 63 patients by measuring the level of serum thyrotropin and the titer of peroxidase antibodies. Abnormal thyrotropin levels were detected in 11 (17%) patients, who in conjunction with the 7 patients with previous thyroid illness, add up to 18 (26%) with altered thyroid function. From 61 patients who were tested for thyroid peroxidase antibodies, 22 (36%) were positive. Of 57 patients without a diagnosis of previous thyroid disease, in whom both the levels of serum thyrotropin and the presence of thyroid peroxidase antibodies had been studied, 24 (42%) presented at least one altered study. Given the high percentage of thyroid alterations in our series of patients, it seems clinically relevant to study the thyroid function and the presence of thyroid peroxidase antibodies in patients with chronic urticaria.
慢性荨麻疹是一种常见病症，其特征为风团和/或血管性水肿持续超过6周。在相当数量的患者中，它表现为自身免疫性疾病，常与甲状腺功能及甲状腺抗体的改变相关。我们在此描述了连续70例诊断为慢性荨麻疹的患者。其中7例（10%）在首次就诊前已被诊断患有甲状腺疾病。通过检测血清促甲状腺激素水平和过氧化物酶抗体滴度，对其余63例患者进行了甲状腺功能和甲状腺抗体研究。11例（17%）患者检测到促甲状腺激素水平异常，这些患者加上之前患有甲状腺疾病的7例患者，共有18例（26%）甲状腺功能异常。在61例接受甲状腺过氧化物酶抗体检测的患者中，22例（36%）呈阳性。在57例既往无甲状腺疾病诊断且已对血清促甲状腺激素水平和甲状腺过氧化物酶抗体进行研究的患者中，24例（42%）至少有一项检测结果异常。鉴于我们系列患者中甲状腺异常的比例较高，对慢性荨麻疹患者进行甲状腺功能和甲状腺过氧化物酶抗体检测在临床上似乎具有重要意义。
