Landini G, Kitano M
Department of Oral Pathology, Kagoshima University Dental School, Japan.
Cancer. 1992 Jun 15;69(12):2917-20. doi: 10.1002/1097-0142(19920615)69:12<2917::aid-cncr2820691209>3.0.co;2-8.
This is the first case report to the authors' knowledge of a primary extracranial meningioma located in the mandible. Ultrastructurally, the tumor cells had intricate cellular membranes and desmosome-like attachment structures. Using immunohistochemical analysis, the tumor expressed both epithelial membrane antigen and vimentin. Although the origin of extracranial meningiomas has been attributed to proliferation of ectopic embryonal nests of arachnoidal cells, the proliferation of perineural cells of peripheral nerves also is possible as a result of the structural and functional similarities of perineural cell and arachnoid cells. The authors suggest that extracranial meningiomas may be more common than published reports indicate because of certain histologic similarities between these tumors, neurilemomas, and solitary neurofibromas.
据作者所知，这是首例关于位于下颌骨的原发性颅外脑膜瘤的病例报告。超微结构上，肿瘤细胞具有复杂的细胞膜和桥粒样附着结构。采用免疫组化分析，肿瘤表达上皮膜抗原和波形蛋白。虽然颅外脑膜瘤的起源被认为是蛛网膜细胞异位胚胎巢的增殖，但由于神经周细胞和蛛网膜细胞在结构和功能上的相似性，周围神经的神经周细胞增殖也有可能。作者认为，由于这些肿瘤、神经鞘瘤和孤立性神经纤维瘤之间存在某些组织学相似性，颅外脑膜瘤可能比已发表的报告显示的更为常见。
