Fresia A E, Currie J L, Farrington J E, Laxman R, Griffin C A
Oncology Center Cytogenetic Laboratory, Johns Hopkins Medical School, Baltimore, Maryland.
Cancer Genet Cytogenet. 1992 May;60(1):60-6. doi: 10.1016/0165-4608(92)90234-y.
Uterine sarcomas constitute approximately 3% of all malignant uterine corpus tumors. Of these, the tumors that originate solely in the stromal elements of the uterine wall are relatively infrequent and have not been well characterized cytogenetically. We report data from a low-grade endometrial stromal sarcoma both at the time of resection and after months in long-term tissue culture. Cytogenetic analysis showed a clonal population of cells with an abnormal karyotype of 46,XX,del(5)(q31.1),der(7)t(6;7)(p21;p22) which remained unchanged in long-term culture. Electron microscopy suggests that these cells are similar to other neoplastic cells in having immature-appearing nuclei surrounded by a relatively mature cytoplasm (with well-developed organelles). Determination of the specificity of these observations must await study of additional stromal sarcomas.
子宫肉瘤约占所有子宫体恶性肿瘤的3%。其中，仅起源于子宫壁间质成分的肿瘤相对少见，并且在细胞遗传学方面尚未得到充分表征。我们报告了一例低级别子宫内膜间质肉瘤在切除时以及长期组织培养数月后的相关数据。细胞遗传学分析显示存在一群克隆性细胞，其核型异常为46,XX,del(5)(q31.1),der(7)t(6;7)(p21;p22)，在长期培养中保持不变。电子显微镜检查表明，这些细胞与其他肿瘤细胞相似，细胞核呈现不成熟外观，周围是相对成熟的细胞质（细胞器发育良好）。这些观察结果的特异性确定有待对更多间质肉瘤进行研究。
