Elena Santiago F, Sanjuán Rafael
Instituto de Biología Molecular y Celular de Plantas, CSIC-UPV, 46022 Valencia, Spain.
Biosystems. 2005 Jul;81(1):31-41. doi: 10.1016/j.biosystems.2005.02.001. Epub 2005 Feb 23.
RNA viruses have high mutation rates and so their populations exist as dynamic and complex mutant distributions. It has been consistently observed that when challenged with a new environment, viral populations adapt following hyperbolic-like kinetics: adaptation is initially very rapid, but then slows down as fitness reaches an asymptotic value. These adaptive dynamics have been explained in terms of populations moving towards the top of peaks on rugged fitness landscapes. Fitness fluctuations of varying magnitude are observed during adaptation. Often the presence of fluctuations in the evolution of physical systems indicates some form of self-organization, or where many components of the system are simultaneously involved. Here we analyze data from several in vitro evolution experiments carried out with vesicular stomatitis virus (VSV) looking for the signature of criticality and scaling. Long-range fitness correlations have been detected during the adaptive process. We also found that the magnitude of fitness fluctuations, far from being trivial, conform to a Weibull probability distribution function, suggesting that viral adaptation belongs to a broad category of phenomena previously documented in other fields and related with emergence.
RNA病毒具有很高的突变率，因此它们的群体以动态且复杂的突变分布形式存在。一直以来都观察到，当面临新环境挑战时，病毒群体遵循双曲线状动力学进行适应：适应最初非常迅速，但随着适应性达到渐近值，适应速度会减慢。这些适应性动态变化已根据群体在崎岖适应性景观上朝着峰值顶部移动来解释。在适应过程中观察到了不同幅度的适应性波动。通常，物理系统进化过程中波动的存在表明某种形式的自组织，或者系统的许多组成部分同时参与其中。在这里，我们分析了用水疱性口炎病毒（VSV）进行的几个体外进化实验的数据，以寻找临界性和标度的特征。在适应过程中检测到了远距离适应性相关性。我们还发现，适应性波动的幅度绝非微不足道，而是符合威布尔概率分布函数，这表明病毒适应属于先前在其他领域记录的、与涌现相关的广泛现象类别。
